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Ampio Pharmaceuticals, Inc. Message Board

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  • The price and volume are holding quite well considering the current market conditions. Almost a safe haven at this point with very strong possibility of significant upside.

  • The tenant up in 310 has a leaky faucet, now be a good employee, grab a wrench, and get up there would you fine fella.

  • Reply to

    charts

    by allenstrode Aug 21, 2015 10:19 AM

    Steve,

    We will have to see if the volume remains strong next week. I noticed on my advanced trading platform some major block trades. DId you see the same? it looked like lots of big trades the last 2 hours of trading. I agree, to show a true breakout the resistance at 4 will be a major indicator.

    Sentiment: Strong Buy

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Rally? Options? Option cycle? Well, you need to look at the option cycle of ampio. This had nothing to do with a sold call option cycle and everything to do with a few heavy block trades by institutional buying. This isnt considered a "rally" by any trader's definition that I know. Keep it simple, Large Block trades that acquired shares that move the stick north. Maybe Steve M can explain to U a little about the charts and how the volume/pricing works and how to track trading and whom is trading and why. Will have to watch this next week to identify any specific patterns. Very important that stock finished at 3 or above.

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Friday's buying was primarily the result of the option cycle expiration forcing closing settlements.

    Sorry but rally is over.

    Sentiment: Strong Sell

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Good luck with it. You have been a rational voice for a long time together with several others like budda/TH3. Very few of those posters left.

    Still think we have a shot at much higher from here, even before the next/final trial results. But then, the yo-yo's will start in about 100% moves from the recent $2.

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Glad to hear you were able to make a partial exit. Can't forget we were bouncing off of $1.94 not too long ago! Best of luck (to us all) with the remaining portion.

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Trusty, yes sold all 3,000 shares I had in one account still have another 4300 in another account. My daughters tuition bill got paid today. the really good news is its her last semester and I'll be finished putting three kids through college. What I found surprising about todays action was it occurred during a really bad day on the market where there was a lot of selling pressure everywhere. Took my lumps today theses were shares I had originally purchased at 6.I will live to invest another day. Hopefully for all this proves to be a real breakout so that others can get out whole or close to whole and possibly ahead. Good Luck to you trusty and all the really nice people who habituate this board.

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Perhaps but AMPE doesn't move like this with this high volume without leaks. We have seen time and time again, the stock goes up before news hits and than WHAMO... good and bad. I suspect there's something good about to happen. No other explanation for this kind of volume. GO AMPE

  • Reply to

    charts

    by allenstrode Aug 21, 2015 10:19 AM

    allenstrode - - .chartwise, my Aug 17 post suggesting a breakout is still valid..3.02 may be temp resistance, but based on volume today, 4x 20 day ave, AMPE could punch thru...3.20 is the 100sma & day high for Apr 20, the day of the collapse, as well as resistance levels from Nov, Dec..so 3.20 may serve as next level of resistance...next is the 4 area with is a significant moving average on a daily & weekly chart..stochastics, rsi, macd, adx suggest more upside possible

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    We've seen this time and time again...a market crash day is a perfect opportunity to manipulate AMPE upwards. I won't give this move any thought until it's sustained for at least a week. Improv - did you manage to sell out at $3 today?

    Sentiment: Hold

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    Most biotech are up today.

  • Reply to

    Surge

    by allenstrode Aug 21, 2015 2:31 PM

    With the general markets crashing, for this to be moving up with PPS and volume, someone knows something -- price volume news...

  • The stock volume and pricing just took a major jump in the last 30 min. We could see another 700k plus on volume and a nice move along with it. AMPE needs to close above 3 and maintain upward trend lines to validate a "Breakout"

  • Reply to

    Markets crashing, AMPE holding very, very well eom

    by kdrobb Aug 21, 2015 12:38 PM

    I think Mike has been beaten up enough and is old enough to understand market cycles and will work toward a valid partnership. This economy is so grossly weak which is finally showing in the true market place that without a partner, AMPE would be doomed. To ride through what is about to happen in the general global market place, without a name brand partner, the game is over here. Hopefully Mike has enough that he can garner a partner out there. What ever he needs to give up to attain this partner strength will be acceptable.

    My gut is that he has something going along a partnership line as the PPS has been holding so very well during this time and the volume supports strength or leakage coming from somewhere.

    GLTA

  • Reply to

    Markets crashing, AMPE holding very, very well eom

    by kdrobb Aug 21, 2015 12:38 PM

    it's not Ampe-specific. Most all biotechs are holding up fine today. Lesser quality was sold earlier, gains were taken in others. I have one good co. (met their Phase III endpoints) that was down 10% yesterday and up today. So, we bounce along the bottom and hope for upside on SPA receipt. Agree with others though, it's likely not to do too much until near end of study unless something surprising happens, like a partnership.

  • (Yahoo clips less than signs... BTW, p LT 0.0001 means 99.9999% chance the result is true - Unlike STRUT to STRIDE supposedly great number of 96%)

    LT 0.0001) acute changes in blood measurements of an established neuroendocrine biomarker.

    The multiple ascending dose study, which used repeat dose studies of the 0.1 mg, 1 mg and 5 mg tablets, administered twice a day (b.i.d.) for one week, demonstrated that all tablet doses were well tolerated with no serious adverse events (SAEs) reported and all adverse events (AEs) were mild and generally similar to those reported with I.V. CR845. Additionally, clinical safety laboratory measurements were normal across all tablet strengths after single or repeat dosing."

  • Actually, it is NOT ASE's, as I pointed out in the OP. Even a cursory read of Phase I data shows that (below). Cara is Derisking the trial, which is smart. Ampio should do the same.

    I've already stated all the risks with the next Ampion trial, beyond unknown risks such as with STEP. Obviously, that problem will not occur again. But the less-experienced investors here should now be aware that unpredictable issues will cause Failure. They might even recall the nonsense spread here from MM's statement that STRIDE will reproduce STRUT efficacy with 96% probability. That is just too low. We just need to see what numbers of KL2's are and what restrictions they put on KL4's to get a better estimate of success.

    "The double-blind, randomized, placebo-controlled trial evaluated the pharmacokinetic and safety profile of single and multiple escalating doses of Oral CR845 in 150 healthy volunteers at a single U.S. site. The single ascending dose study, which included six tablet strengths ranging from 0.1 mg to 10 mg, demonstrated a mean oral bioavailability of 10% across all dose groups under fasting conditions, with a range of maximum plasma concentrations of CR845 bracketing the concentrations seen in previously successful Phase 2 trials with I.V. CR845. All tested dose strengths were also shown to be active at the kappa opioid receptor, as assessed by statistically significant (p

  • steve, you were looking at a breakout that didnt materialize. I noticed we had a one day increase in volume and price but it appears to be stuck in the mud. What are your charts telling you? Be interesting to see what this does in the next few weeks with anticipation of study and buzz around Optina.

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