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Vertex Pharmaceuticals Incorporated Message Board

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  • Reply to

    THE STREET RATING SYSTEM

    by gladpick Jul 9, 2014 12:17 PM

    Congrats to those who bought in the high 50's & low 60's.

  • Reply to

    valuation

    by papaalien2000 Jul 9, 2014 10:56 AM

    Verity, the Traffic trial yielded the absolute change of 3.6% for 600mg Lum within the group, and 4% relative to placebo. The Transport yielded a lower value of 2.6%. These compared with the Phase II 4+4 wk data of 3.4% within group and 6.7% relative to the placebo. All numbers quoted above were absolute ones. The Ph II data were noisy. As you stated, Ph II data of 661/Iva combo gave slightly better results. After 4 wks' of the 100mg 661 dosing, FEV1 changed by 4.8% absolute (9% relative) within group as well as relative to placebo.

    The most important results from the Ph III data are not FEV1 changes, but the significant reduction in the frequency of pulmonary exacerbations that participants experienced, and the high number(90%) of participants in the rollover study.

  • Reply to

    FORM 8-K

    by thirdmeinvestor Jul 9, 2014 5:55 PM
    johnf50@rocketmail.com johnf50 Jul 9, 2014 8:38 PM Flag

    That was my initial caution. Another way to look at this, is that it implies they expect cash flow development 2 to 3 quarters ahead of current pace, or they just get more debt. But no dilution is a positive.

    J

  • Reply to

    FORM 8-K

    by thirdmeinvestor Jul 9, 2014 5:55 PM

    At first when I read it I was disgusted that they need money with 1B on hand. Reading the details, it show they are confident it can be paid off. At least it's a loan NOT a dilution or secondary offering of additional stock.

  • Reply to

    valuation

    by papaalien2000 Jul 9, 2014 10:56 AM

    I was actually trying to figure out whether 661 would be better....I reviewed all the numbers and frankly am having a hard time comparing. Are the phase 3 results for 809 compared to placebo or within group? I'm trying to get apples to apple to compare phase 2,3 for 809 and phase 2 for 661. The best I can do is say that for the # with greater than 5% relative improvement is quite a but higher for 661. That bodes well for it being better. Anyone able to figure out how to compare? I'm having a problem with the is it compared to placebo or within group?

  • Reply to

    FORM 8-K

    by thirdmeinvestor Jul 9, 2014 5:55 PM

    I was thinking vertex is working on a collaboration with Ataluren. Cf is its only priority program now and that could get vertex to 95% of the population. I'd think that would be enough cash for that narrow of a collaboration.

  • Reply to

    FORM 8-K

    by thirdmeinvestor Jul 9, 2014 5:55 PM
    johnf50@rocketmail.com johnf50 Jul 9, 2014 8:06 PM Flag

    I don't know how many times I posted they needed money. 300 M seems either too small as I thought a billion based on development forecasts and cash flow projections - OR - this is an incredibly bullish sign that Vertex management reasonably projects that (A) they will increase revenue by additional indications, partnerships, or sale of non strategic assets, or (B) accelerate development, or (C) any combination thereof.

    So how do you read it? Bull case or Bear case. I am leaning towards Bull.

    J

    Sentiment: Strong Buy

  • Vertex is borrowing $300M at an interest rate of 7.2%. The purpose for this loan is said to be related to strengthening financial position:

    [[ The credit agreement is intended to strengthen our financial position as we invest in our key development programs in cystic fibrosis and in research for future medicines, including potential collaborations to support priority programs. ]]

    Vertex may need funds for supporting Phase 2 trials of reversing, and blocking AIDS using caspase-1 inhibitor, VX-765.

  • Is a joke. Rated VRTX a sell when it was trading in high 50's, low 60's. Now that it is in the upper 90's it rates it a hold. A very good rating system if you love losing money!

  • Reply to

    valuation

    by papaalien2000 Jul 9, 2014 10:56 AM

    Since release of TRAFFIC/TRANSPORT data, analysts have been modeling a discount on the 809/770 pricing and still predicting peak annual sales averaging 7 billion worldwide (and it could be more since these are hypothetical projections). Long term efficacy data regarding decreased rates of infection and hospitalization, as well as slowing the progressive loss of pulmonary function will be a important factors in getting better pricing from payers. If data coming from VX 661/770 Phase 2 trials currently underway shows better improvement in absolute FEV-1 compared to TRAFFIC/TRANSPORT, the stock will get higher valuations seeing the likelihood of better pricing for the eventual use of 661/770 in 508d homozygotes and eventually in the 508d heterozygotes when combined with second generation correctors.

  • Reply to

    valuation

    by papaalien2000 Jul 9, 2014 10:56 AM

    I think the key is price will be dependent on FEV1, not adoption. They simply can't charge as much for the combo as they would have if they had achieved 6%.
    It will be interesting to see what impact this will have on Kalydeco mono therapy pricing.

  • some time ago JPM had an estimate on VRTX share price after positive combo results. If I remember correctly it was about $100 on 3% FEV1 and about $150 on 6% FEV1. Now that we know that the combo FEV! is about 3% the current share price supports the JPM prediction. However, a correlation of FEV1 and share price would suggest that sales of combo is dependent on FEV1. But does the number of patients using the combo really depend on FEV1? I guess not, once approved CF patients will use the combo, no matter what the FEV1 number is. Having said that, what is a realistic share price to be expected on approval?

  • Reply to

    History repeats itself

    by jrus2010 Jun 29, 2014 11:34 AM

    Usual pullback with VRTX has been 10-20% from peak within 2-4 weeks after big moves. We could see this amplified if there is large market correction that occurs simultaneously.

  • ORFG closes in on Utah oil refinery tipped by owners to be worth nearly $70 million once up and running

  • Profit-taking ahead of market downturn and increasing instability will affect entire biopharma sector, most especially those that have had a very nice recent increase. Keep an eye on the sector indices.

  • and they are blowing $320,000 on one patient.

  • PCD or immotile cilia syndrome is another genetic disease and lung manifestations are exactly like CF. In fact my major worry about VX 809 and VX 770 trial was that a significant CF patients has PCD as well. Trial turn out to be okay and I think VRTX should take a shot at this indication with VX 770 and VX 809 and if by good luck we show benefit, you are looking to add another 25000 plus patients in USA only. PCD has a foundation and it is an orphan disease and fits with Dr. Jeff Leiden criterion. I wish my post can be forwarded to VRTX chief scientist.

  • It will be nice to have input from VRTX leadership regarding AIDS and VX 765 potential. They should give us pipe line update especially about VX 509. I have not heard about MRI and synovial joint biopsy trial results nor I have seen any publications? Look at SLXP, how they have grown from a 1 B company to a 9 billion company. I have posted couple of years ago that I wish VRTX acquires SLXP and sells Incivek through their gastroenterology sales team. Just having revenues from CF is repeating mistake of the past i.e Hep C.

  • Consider the possibilities: At a minimum the above article suggests the possibility of using VX 765 in every HIV infected patient. VX 765 would prevent the the infected patient's self destruction of it's own CD4 T cells that seems to naturally occur in response to HIV infection. Furthermore, it would prevent the emergence of resistance to ARV drugs, and thereby enhance the effects of ARV therapy. Lastly, it may prevent the inflammatory complications of long term ARV therapy which include premature aging and death due to heart disease and dementia. This would be an incredible step forward in the treatment of HIV worldwide. Another first to market opportunity for Vertex with incredible benefit to a large and suffering population worldwide.. It could reduce health care costs overall by preventing the emergence of HIV resistance requiring changes in ARV treatment, prevent the development and need for treatment of the long term complications of ARV drugs (heart disease and dementia) and could be part of a treatment that actually eradicates the latent HIV reservoir in patients being treated for a potential cure for HIV infection.

VRTX
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