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MRI Interventions, Inc. Message Board

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  • Reply to

    easy if just widget selling

    by stevemed Aug 3, 2015 10:00 AM
    rxdavemull@sbcglobal.net rxdavemull Aug 28, 2015 10:51 AM Flag

    Very true.My brother ran into this with his neurosurgeon in Dallas.Tops in his field.He has his procedure for doing brain surgery and is resistant to change.I got the impression that for him to adopt something new it must be a game changer both in cost savings and time savings.Maybe Clearpoint is such a gamechanger but so far the neurologists have not adopted it.

    Sentiment: Hold

  • with options, for a job well done!!! Shareholders are really seeing the benefits of new management (please note the sarcasm). Meanwhile on that same day they file an S-3 for $50 million. Not that they would ever be able to raise that much in one tranche, but that would be the ultimate kick in the nuts. That's over 100% dilution!

  • Reply to

    Every one should read this

    by suzysaucon Aug 11, 2015 2:34 PM
    rxdavemull@sbcglobal.net rxdavemull Aug 19, 2015 3:56 PM Flag

    The technology is good.Hospitals are not adopting the software a fast as they had thought.Until major hospitals adopt this technology,it will be awhile before MRIC sees any appreciable movement up in the stock price.But at this price it is definitely a buy.

    Sentiment: Strong Buy

  • Reply to

    l.plude

    by l.plude8295 Aug 14, 2015 7:48 AM
    rxdavemull@sbcglobal.net rxdavemull Aug 19, 2015 3:51 PM Flag

    Sometimes a stock does the unexpected.At this point just average your cost basis down and extend your time horizon.Eventually it will recover.

    Sentiment: Strong Buy

  • Reply to

    l.plude

    by l.plude8295 Aug 14, 2015 7:48 AM

    When is he going to RETIRE ?

  • Reply to

    l.plude

    by l.plude8295 Aug 14, 2015 7:48 AM

    Good time for you to avg down, pick up a few K shares and you'll be under $1 avg in no time.

    Or sell, and buy Medtronic, much safer investment that way, but doubt it will make a dent in your retirement fund needs.

    Sentiment: Strong Buy

  • Taurine increases hippocampal neurogenesis in aging mice.

    Aging is associated with increased inflammation and reduced hippocampal neurogenesis, which may in turn contribute to cognitive impairment. Taurine is a free amino acid found in numerous diets, with anti-inflammatory properties. Although abundant in the young brain, the decrease in taurine concentration with age may underlie reduced neurogenesis. Here, we assessed the effect of taurine on hippocampal neurogenesis in middle-aged mice. We found that taurine increased cell proliferation in the dentate gyrus through the activation of quiescent stem cells, resulting in increased number of stem cells and intermediate neural progenitors. Taurine had a direct effect on stem/progenitor cells proliferation, as observed in vitro, and also reduced activated microglia. Furthermore, taurine increased the survival of newborn neurons, resulting in a net increase in adult neurogenesis. Together, these results show that taurine increases several steps of adult neurogenesis and support a beneficial role of taurine on hippocampal neurogenesis in the context of brain aging.

    Stem Cell Res. 2015 May;14(3):369-79

  • I got in at a thousand shares $1.59. Looks like I'm doomed. My banker friend has 30,000 shares and he says it's a good retirement stock. Hmmmmm.

    Sentiment: Hold

  • Reply to

    Every one should read this

    by suzysaucon Aug 11, 2015 2:34 PM

    There is a great video attached to the article as well.

    Long term play, buy forget about it for a couple of years.

    Sentiment: Buy

  • Reply to

    Every one should read this

    by suzysaucon Aug 11, 2015 2:34 PM

    Agreed it's a great story, that doesn't help the fact the everyone is getting smashed in this stock. I've said it before, since I am long and wrong right.... the technology has potential, but this has been a horrible investment. I've been here since it was Surgivision (private) and it has been high on promise and low on delivery/performance. At the end of the day, we as investors are here for one thing only..... to make money!!! The company's management, prior and present have not lived up to their end.

  • NorthJersey.com

    July 25, 2015

    Bringing Buddy back: Teamwork, technology restore a Parkinson’s patient

    By Lindy Washburn, Staff Writer | The Record

    http://www.northjersey.com/news/bringing-buddy-back-teamwork-technology-restore-a-parkinson-s-patient-video-1.1380917

    Buddy Cordato is parked in the recliner in front of his 42-inch television. It’s the middle of February, and there’s basketball on ESPN, a Gatorade in his hand and 37 staples in his head.

    He is waiting for what sounds, even to him, like a miracle.

    BringBuddy1
    Thomas E. Franklin Staff Photographer
    Buddy Cordato taking his first steps at the North Jersey Brain and Spine Center in Oradell after getting his brain stimulator turned on.

    Seventeen days earlier, a brain surgeon at Hackensack University Medical Center drilled two nickel-sized holes in his skull and guided a wire as fine as a strand of angel hair through each one. The target was a pea-sized region deep in the brain that controls movement.

    A week later, the surgeon added extensions to the wires, threading them under his scalp and down his neck to connect them to a small battery pack pack implanted in his chest.

    Azmi1
    Thomas E. Franklin Staff Photographer
    The neurosurgeon: Dr. Hooman Azmi threaded thin wires into each side of Buddy's brain to help control movement

    Now Buddy is waiting for the device, a deep brain stimulator, to be turned on.

    He has Parkinson’s disease, a motor disorder that has no known cause or cure. His arms and legs shake all the time. He often feels depressed. He walks, but very slowly.

    When the stimulator is turned on, it will send tiny pulses of electricity to his brain to interrupt its faulty circuitry. The surgeon says it will control Buddy’s tremors, relax his rigidity and smooth and speed his movements.

    Gupta1
    Thomas E. Franklin Staff Photographer
    The neurologist: Dr. Fiona Gupta turned on the stimulator and fine-tuned its tiny pulses of energy.

    Almost make him normal again.

    Without the operation, Buddy says he had nothing to hope for. Now he has plenty: “I hope I stop trembling as much. I hope I calm down. I hope I get back to a way of life I’m comfortable with — walking around the neighborhood, visiting friends, family.”

    But today, the onetime Verizon cable technician, who used to gaff his way up utility poles, shuffles to the kitchen. At 57, his 6-foot frame is stooped and hollowed out; his weight has dropped 30 pounds from his working days. He’s often overwhelmed by anxiety. Every four hours, night and day, he swallows pills to try to control the relentless trembling in his arms and legs. Yet still he shakes.

    Buddy’s life has shrunk to this second-floor apartment, the television and visits from Kevin Sweeney, his friend since they lived across the street from each other in Jersey City during high school. Some people are brothers even if they’re not blood kin, Buddy says. Kevin’s one of those.

    Sweeney
    Thomas E. Franklin Staff Photographer
    The friend: Kevin Sweeney stood up for Buddy when he needed help. He found a doctor and took Buddy to appointments.

    Without Kevin — who stood up as Buddy’s best man and as godfather to his oldest son, who took his call when Buddy couldn’t face life with Parkinson’s anymore, who found him the right doctor and drove him to the appointments — without him, Buddy says, he wouldn’t be here. By the time they met the neurosurgeon last October, Buddy was ready to end it all.

    What Dr. Hooman Azmi described to them sounded wacky. Two holes in his head and some wires?

    Few procedures in medicine have such dramatic and quick results, Azmi said. One minute the patient’s arm flaps back and forth across his body and his head shakes. The next minute — after the device is turned on — the patient sits without moving, totally calm. This was the tantalizing prospect that Azmi presented to Buddy and Kevin when they met.

    “I’m giving my life to his hands,” Buddy says, marveling that he’s come through the surgery and is now ready for the next step.

    Turn-on day is Monday, in four days.

    Buddy
    Thomas E. Franklin Staff Photographer
    The patient: Buddy Cordato, desperate to relieve his Parkinson's symptoms, underwent surgery to implant a deep-brain stimulator.

    Buddy keeps the surgery wounds clean, and hopes.

    Heartbreaking decline

    Parkinson’s disease struck Buddy — whose given name, used only by strangers, is Victor — unexpectedly, as it does most people.

    He was taking a safety recertification course at Verizon in 2009. When he had to climb a telephone pole, he couldn’t move his right leg or lift himself up. A few days later, in a parking lot, his leg gave out again. “I was like, ‘What the hell? What’s happening?’” he says.

    Buddy3
    Thomas E. Franklin Staff Photographer
    Cordato feeling the surgical staples left after electrodes were implanted in his brain to help control the tremors and spastic movements of the disease.

    It took months to get to a diagnosis.

    Buddy became one of more than a million Americans with Parkinson’s disease, a number that includes about one in 100 people over age 60. He was just 51 when a doctor broke the news. Actor Michael J. Fox, the face of Parkinson’s for many Americans, was diagnosed in 1991 at age 30.

    “In the beginning, I didn’t know how bad it was going to get,” Buddy says from the recliner. He gets emotional talking about his decline, and his eyes well up. Buddy tried to focus on positive examples, like Fox and Muhammad Ali, but he was devastated.

    BuddySweeney
    Thomas E. Franklin Staff Photographer
    Kevin Sweeney, left, a friend since high school, helped Buddy Cordato get through the darkest days of coping with Parkinson's disease.

    He stopped working four years ago, about two years after the symptoms appeared. His income plummeted, but he had good health coverage — primarily Medicare. Divorced, he lives with his oldest son, who is 24, in a plain apartment near the Hackensack River in Bayonne. It’s a no-frills home for bachelors: The only decorations are the photos of his two boys as college athletes. The refrigerator is stocked with Gatorade and water bottles. The walls have wooden grab bars in case Buddy loses his balance.

    For a while, medication kept his symptoms at bay. The drugs were a synthetic replacement for dopamine, a chemical in the brain that communicates among nerve cells and coordinates movement. The brain cells that produce dopamine die in patients with Parkinson’s. Their absence causes the nerves to fire erratically, leading to uncontrolled tremors and other involuntary movements.

    The problem is that as the disease progresses, patients must take the medication more frequently or at higher doses. Over time, its effects wear off more quickly. The “on” time, when the drug is working, grows shorter, and patients have to plan their lives around ever-shortening cycles of on- and off-time.

    “Every four hours I take it to get 25 minutes of relief,” Buddy says.

    The drugs’ side effects include, for some, hallucinations and more tics and involuntary, jerky movements. Buddy has a 3-inch scar on his forehead from hitting his head when he fell during one such hallucination. Another time, he fell while sleepwalking and broke his finger. It is permanently bent.

    “Your whole life changes,” he says. “There’s not a minute of the day you don’t think about it. There’s not a situation you don’t deal with it — your eating habits, your cleaning habits, every minute.”

    He mourns that he’s not been the dad he wanted to be to his son — never even grabbed a beer together after work. Instead of being the man in charge, he’s the one his son looks after. To Buddy, that’s not right.

    Next stop: surgery

    As his condition worsened last year, a long, scary delusional episode landed him in the hospital for days. Kevin took it upon himself to find a doctor who specialized in Parkinson’s. He ended up taking Buddy to Dr. Dev Raj Gupta, chief of neurology at Hackensack, who altered Buddy’s prescriptions and bought him nine months of good time.

    “Then it just stopped,” Kevin says. The drugs lost much of their effectiveness.

    It was time to see a surgeon.

    The day after he watched the New England Patriots win the Super Bowl, Feb. 2, Buddy arrived at Hackensack early in the morning for the operation on his brain. Although not everyone with Parkinson’s is a candidate for this surgery, he had passed all the screening tests.

    It was performed in an MRI suite rather than a standard operating room. Azmi is one of a few neurosurgeons to rely on real-time MRI images, rather than waking a patient midway through the operation, to check on the placement of the electrodes in the brain.

    The huge magnetic-resonance imaging machine, with its 4-foot cylinder and gurney, dominated the room. Surgical lights reflected from gleaming operating tools: a titanium drill and its bits, retractors, scalpels, and a brain-navigation device that looked like some 21st-century version of an ancient mariner’s sextant. The surgeon’s custom wooden stool, with his name stenciled in cursive, stood ready.

    “The last thing I remember,” Buddy says, “the guy said, ‘You’re going to go to sleep now.’”

    Azmi decided to specialize in this surgery after witnessing its effects while he was a surgical fellow in Cleveland in 2006. Now director of the division of movement disorders at Hackensack, he’s implanted deep-brain stimulators in more than 200 patients. One of his favorite cases was a man with a severe tremor who yearned to hold his long-awaited first grandchild. “Because his hands were continuously shaking,” he was afraid to, Azmi said. With deep-brain stimulation, the shaking stopped and he was able to hold the baby safely.

    Until recently, patients had to be brought out of anesthesia during the procedure to make sure the electrodes were properly situated and didn’t affect speech and memory. Some potential patients feared being awakened during brain surgery and decided not to have the operation. Evidence shows that both methods are equally effective, and Azmi now teaches the MRI-guided technique to other neurosurgeons.

    In the operating suite that Monday, Azmi fastened a frame around the head of the sleeping patient and tightened the screws against Buddy’s skull. It was bolted to the table, so Buddy’s head would stay perfectly still — crucial during a procedure where distance within the brain is measured in millimeters. The device contained a halo-like coil used to make images of the brain in the MRI.

    The surgeon centered a blue drape at the top of Buddy’s head, leaving a small circle open to reveal the shaved scalp where the incision would be made. A nurse stuffed earplugs in Buddy’s ears to muffle the clanging of the MRI.

    Azmi mapped the electrode’s route to its target, a “tiny little thing” known as the subthalamic nucleus, located in the deep brain on the same horizontal plane as the ears. He wanted to avoid blood vessels and what neurosurgeons call the “eloquent” — useful — areas of the brain.

    He taped a grid [SMARTGrid®] of dots to Buddy’s scalp; these would be visible in the MRI images and create a sort of graph-paper overlay of the brain. When he had plotted the best angle to get to the subthalamic nucleus, he calculated where the point of entry through the skull would be. He cut through the scalp and pulled it back to reveal the skull.

    The drill whined like a dental bit, cutting a nickel-sized hole through the three-quarter-inch-thick bone to the dura, the brain’s protective coating.

    When the hole was open, the doctor attached the [ClearPoint®] guidance system above it with little screws. It had four knobs, each controlling a different aspect of the pathway the wire would follow. The assistants slid Buddy into the MRI machine for an image of his brain, and Azmi twirled the knobs to align the trajectory.

    Once certain of the angle, he started pushing a thin ceramic tube inward. Millimeter by millimeter, it advanced through the cortex to the subthalamic nucleus.

    While some 2,000 patients a year in the United States undergo deep-brain stimulation surgery for Parkinson’s, doctors don’t completely understand how it works. Tiny electrodes at each wire’s tip emit high-frequency electrical pulses that interrupt the brain’s circuitry in the area that controls movement. Some liken it to a pacemaker for the brain. For Parkinson’s patients, brain activity tends to be “over-synchronized” — in lock step when it should be more variable — in that region. The device’s electrical signals break that lock-step pattern to create more flexibility. The amount of stimulation is customized for each patient.

    Rehab
    Thomas E. Franklin Staff Photographer
    Working with physical therapist Manthan Patel has helped Cordato regain strength in his legs and ease the trembling. Weeks after surgery, he was walking briskly with a cane.

    This procedure was first approved for Parkinson’s patients in 2002. When used in other parts of the brain, it is also approved for some patients with obsessive-compulsive disorder and research is under way to gauge its ability to treat epilepsy, Tourette’s syndrome and depression. Animal tests are assessing whether it can help with physical rehabilitation after a stroke. It’s reversible — the wires can always be removed.

    Experts such as James Beck, vice president for scientific affairs at the Parkinson’s Disease Foundation, say it’s important to note that deep-brain stimulation surgery does have risks, such as infection at the surgical site, usually in the chest, and the potential for some subtle but persistent side effects. One recent study identified an impact on speech. The surgery works best to alleviate the symptoms the medication addresses, such as tremor and rigidity, and does not address depression or fatigue.

    Azmi monitored the progress of the guide toward Buddy’s subthalamic nucleus. The ceramic tube contained a very fine straw. When it was in position, Azmi removed the tube and left the straw. Then he slid the electrical wire through the straw, and peeled the straw away, leaving the electrode in place. He capped the hole with plastic, locking the electrode in place. He then repeated the procedure on the brain’s other side.

    Kevin was the first person Buddy called when he woke up later that day with a big bandage on his head. He told his friend he felt great.

    “I felt different,” Buddy recalls. “I felt like I had life again.”

    While they hadn’t turned on the device yet, the micro-abrasions the surgery had caused on that tiny area of the brain had stimulated a beneficial effect. “I had a whole new outlook,” Buddy says. “I don’t know if it’s in my mind, or physical — or a miracle.”

    ‘It’s about recovery’

    Seventeen days later, after resting at his apartment with hour upon hour of ESPN, Buddy gets a ride with Kevin to the offices of the North Jersey Brain and Spine Center in Oradell for turn-on day.

    It’s hard for him even to walk in because of his Parkinson’s symptoms. He’s stopped all his meds for 12 hours, as instructed, so the effects of the electrical stimulation will be undiluted when it is turned on. His legs and hands tremble. From the handicapped parking space, Buddy makes his way ever so slowly, using a cane.

    He feels extremely anxious, he admits. Kevin sits nearby, running his Wallington ink supply business from his cellphone.

    Buddy Gupta
    Thomas E. Franklin Staff Photographer
    Dr. Fiona Gupta, a neurologist at North Jersey Brain and Spine Center in Oradell, programming Cordato's deep-brain stimulator through a pacemaker in his chest.

    Finally, Dr. Fiona Gupta, the neurologist in charge of the deep-brain stimulation program, is ready for him in an exam room. She chose neurology as a specialty after her mother, also a physician, developed multiple sclerosis in her 40s and deteriorated quickly. Rather than specialize in that disease, however, which felt too close for comfort, she decided to work with deep-brain stimulation patients. Unlike many patients with chronic neurological conditions, for those with this surgery, she says, “It’s about recovery.”

    In the exam room, she holds a controller — like a television remote — over Buddy’s chest.

    “We’re going to start,” she says. “I’m going to turn on the side that controls the right side of your body, OK?” Today’s job is to make sure everything works and assess Buddy’s tolerance for the electrical stimulation. The settings will be refined in the months to come.

    She asks Buddy to tap his thumb and forefinger together. “Any pins or needles?” she asks. She asks him to repeat as she says, “It’s a sunny day out.” If the stimulation is too great, or the electrode slightly out of place, he’ll feel a tingling sensation or slur his words. He doesn’t.

    “You can see a bit of a difference,” Gupta says. “The side that is not stimulated is tremulous, and the side that is stimulated, with a very low level, is responding nicely.”

    She increases the voltage.

    “I feel my leg feel a little better,” says Buddy, staring intently, straight ahead.

    The tremors are gone. His right hand has stopped vibrating.

    She then goes through the process with the left side.

    Finally, with both sides on, she asks Buddy to walk in the hallway.

    He stands up nervously, wondering whether to take his cane. “Take it but don’t use it,” Kevin says.

    His gait is smoother. The freezing in midstep is gone. His pace is quicker.

    Rehab 2
    Thomas E. Franklin Staff Photographer
    One positive effect of the surgery is that Cordato has been able to hold his hands steady with only minimal shaking.

    “It’s a pretty immediate response,” says Gupta. “It’s very rare in medicine to see something so immediate.”

    With that basic setting on, Buddy goes home with instructions to reduce his doses of medication slowly over the next four weeks.

    A month later, Buddy and Kevin bound into the office in Oradell for their next visit, a fine-tuning of the device.

    Buddy sets a brisk pace. He has no cane.

    “How ya doing, hon?” he asks, leaning in to a reporter for a hug and kiss. He’s feeling good, he says. The scars from the staples on his head are healed. He’s sleeping through the night. He goes out every morning — he’s driving again — to the coffee shop, he says. “I’m eating really good.” He’s cut the number of pills he takes to one-fourth of what it was before surgery.

    “I feel a lot calmer, no stress,” he says. “I’m not letting anything bother me,”

    Gupta is pleased: “If I just met you and didn’t know you,” she says, “I would not know that you have Parkinson’s.”

    She’s encouraged by the reduction in his medication and wants him to keep lowering the dosage.

    Gradual adjustment

    hile the tremor on his right side is gone, the left side still shakes a little. Gupta changes the settings on his stimulator slightly, hoping to eliminate it.

    Buddy asks about a speech problem he’s been having. “I’m having a hard time communicating,” he says. “The words are in my head, but they won’t come out. … I’m not pronouncing the words correctly all the time,” he adds, “but people are getting the gist of what I mean.”

    Rehab 3
    Thomas E. Franklin Staff Photographer
    Buddy Cordato walking with physical therapist Manthan Patel as he worked to regain strength and mobility three months after the deep-brain stimulation procedure.

    Gupta tells him it will get better. She attributes it to the aftermath of the surgery and his brain’s adjustment to the stimulation. The circuitry of the brain has changed, she says, and “It’s almost like you have to retrain yourself in how to speak and walk and talk.” She recommends some speech therapy, along with his physical therapy.

    For Buddy, the ability to just walk around the neighborhood and sit without shaking is a blessing, he says. Getting off his pill regimen has been a great relief. “Everything I went through, it was worth it,” he says.

    Kevin notes Buddy’s new outlook. “He’s more upbeat, optimistic,” he tells Gupta. “Completely different.”

    Buddy reminds the doctor about the holiday party she told him about. All the guests have nickel-sized bumps in their scalps — they’re alumni of Azmi’s surgery. He wants an invitation. “Help me find a girlfriend,” Buddy says. “I’ll be indebted to you for life.”

    Gupta laughs and says the patients she monitors have become like family.

    With new instructions about his medication dosage and another appointment in six weeks, the two men head out.

    Buddy seems almost jaunty.

    “If this is as good as he gets – physically, it’s OK,” says Kevin, trailing behind. “He’s a new person. … He’s fun to be around.”

    He may not be back to how he was before Parkinson’s, says Kevin, but “he can live now.”

    Email: washburn@northjersey.com

    Sentiment: Strong Buy

  • Chan needs to pump this or deliver. I left this company for other opportunities. Growth and revenue expectations are not materializing fast enough. Cash burning machine. MRI is not doing well either. These small speculative stocks are akin to gambling. I just need one to come in and so far a bust. JUNK

  • Take a look at CTSO (Cytosorbents). Beginning a significant rebound this week from some past staffing issues that impacted Q1 and Q2. Rest of this year and beyond will be fantastic. Do a little research and I think you will be impressed. Just getting off the ground and is already several years into sales in Europe and expanding. Added Saudi last month.

  • Reply to

    if ClearPoint so golden

    by stevemed Aug 4, 2015 8:53 AM
    stevemed@sbcglobal.net stevemed Aug 5, 2015 1:03 PM Flag

    the ablation lasers have a navigational component to their software for intraoperative mri

  • Reply to

    if ClearPoint so golden

    by stevemed Aug 4, 2015 8:53 AM

    Apparently the management can not get it off the ground. If it were that good it would sell itself and create buzz. Perhaps it ain't golden after all....

    Sentiment: Hold

  • anyone know?

    Sentiment: Strong Buy

  • an instrument company would purchase company and incorporate the clearpoint navigation for the surgeries their surgical instrumentation addresses.

  • stevemed@sbcglobal.net by stevemed Aug 4, 2015 8:51 AM Flag

    is bulky and an unnecessary add on for most navigational needs as the instrument players are incorporating navigational software into products.

  • are a becoming a dime a dozen incorporated into the mfg mri interoperative lasers, and other inteoperative instrumentation

  • Reply to

    easy if just widget selling

    by stevemed Aug 3, 2015 10:00 AM

    If anything, MRI as a long term going concern has been reaffirmed. This volatility is a sign of interest through PIPEs. No other way to est a large stake with such low volume, and why we saw the large pull back up on Friday.
    We've new partners.

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