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Prana Biotechnology Limited Message Board

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  • I think this was meant to be posted here in response to another post...this is exactly what I a referring to but more to the point imtom--

    imtom9930 • 5 hours ago

    1 users liked this posts users disliked this posts 0
    Reply

    Beg to differ...but I think the outliers identified by ITMs' analysis suggest that their are problems yet to be identified and adjusted for...As per effectiveness...many consider the dosage given in Imagine trial to be quite low as well. Not a 'problem,' as small placebo group clearly was, but it did reinforce that PBT2 is safe at that dosage...Effectiveness at higher doses is yet to be demonstrated.

    Sentiment: Strong Buy

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    Yes last I checked they had only 9 employees working at Prana. Good to know that's probably why they went to Dr. Reddy's lab.

  • TB you are doing the right thing. Keep it up. I really admire your strength.

    Sentiment: Strong Buy

  • How sad. I recently downloaded a live version of "Gentle on My Mind" which is absolutely fantastic. A talented guy.

    I'm a strong believer that home is where you get the best care. Of course, at some point, that's no longer possible. Who's right in this mess? Who knows. That's for the family to hash out.

    I do wonder if the wife is just all too eager to be done with the problem, because I'm sure they have 24/7 professional care at home. How difficult can it really be with all that help. And sending him out on tour with AD because it would benefit him? Really? That was all about the money. (Didn't Sinatra's wife do the same thing.)

    On the other hand, if the daughter is complaining about putting him in a nursing facility, where is she? Let's put it this way - I'm one of five siblings. Since my father got AD, three of their lives have not changed one iota. The other one, only slightly so. My life has been turned upside-down. I suspect that's the way it is in most families, some take responsibility, some don't. Ironically, it's the ones who take the least responsibility for GIVING care that seem to have the strongest opinions about HOW to care for the AD patient.

    And that's just one reason why AD causes so much stress for a family.

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    I remember you mentioned limited numbers of employees at PRAN currently. PRAN may have to rely on a CMO to manufacture its product before acquired by a big Pharma like PFE or other companies. CMC effort for commercialization requires cGMP facility with organizations such as facility with metrology, manufacturing, operation, quality control, quality assurance/Quality engineering/validation. it seems once PRAN has a licensed product, it will be sold or acquired very quickly.

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    Indeed.

  • NASHVILLE, Tenn. (AP) Glen Campbell's Alzheimer's disease has progressed to the point where he needs full-time professional care, his wife said Thursday, explaining her decision to place the singer in a long-term care facility and responding publicly for the first time to criticism from Campbell's eldest daughter.
    In an email to The Associated Press, Kim Campbell wrote that doctors persuaded her earlier this spring to discontinue care at the family's home, drawing criticism from Campbell's daughter Debby.
    "It is crushingly sad to see him afflicted with Alzheimer's but indulging those feelings does not help him," Campbell wrote, adding, "I am his wife and no one wants him home more than me but I must do what is in his best interest."
    Debby Campbell told Country Weekly magazine last week that she objected to the move and that she and Campbell's eldest children heard about it through news media reports. She also said she did not believe family members in Nashville, where the Country Music Hall of Fame member now lives, were spending enough time with him.
    Campbell, 78, was diagnosed with Alzheimer's in 2011. He issued two albums and went on a world tour following the diagnosis. At the time, Kim Campbell said the tour was a way to help her husband combat the brain-ravaging disease and spend time with his family members, including Debby, who made up his band and traveled with him.
    Glen Campbell has eight children, including three with Kim Campbell, his wife of 32 years. She says she spends time with her husband every day and that two of his children who live in Nashville visit weekly. Beyond that, she says she organizes activities for the Grammy Award-winning singer of such hits as "Rhinestone Cowboy" and "Wichita Lineman."
    .... "He has activities and therapies to stimulate him and help him experience daily moments of success. His life is filled with and laughter and he is being cared for round the clock by people who specialize in Alzheimer's care and happen to adore him

    Sentiment: Strong Buy

  • Reply to

    Iron in neurodeg disoders

    by pivalde 12 hours ago

    itm, I asked a couple of hours ago what you meant by "iron and copper platelets" that you felt should be monitored. I asked a hematologist and he had no inkling of those terms in a medical sense. He wants to refer you to a hardware store but the owner has his iron and copper platelets on shelves and tagged $2.12 and doesn't want any stranger messing with them.

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    You have to ask yourself why did Prana go through all the extra steps to change manufacturers after the first Phase II. For a trial it is only a some amount needed to be maufactured. And we already know from PBT1 there were impurities within the manufactured drug besides other issues.

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    It's certainly been bothering me since they first announced Dr Reddy. No serious watchdog in India!!

    Sentiment: Strong Buy

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    That's exactly why I started looking into this vine. I wonder about the quality control and since it is a metals based treatment, whether an adjuvant could have played a role in the "fluke" or treated group. I agree. India is not my first choice. As CH posted recently in the prior 2A trial they did not use Dr. Reddy.

    Sentiment: Strong Buy

  • Beg to differ...but I think the outliers identified by ITMs' analysis suggest that their are problems yet to be identified and adjusted for...As per effectiveness...many consider the dosage given in Imagine trial to be quite low as well. Not a 'problem,' as small placebo group clearly was, but it did reinforce that PBT2 is safe at that dosage...Effectiveness at higher doses is yet to be demonstrated.

  • Reply to

    PBT2 Manufacture

    by interestingtome 12 hours ago

    Dr. Reddy certainly can produce PBT2 in mass quantities. I think they may be the seventh largest generic manufacturer and growing. My concern is quality. Most of the pharmaceutical manufacturers are now from India and they have been notorious for poor quality assurance. Just search FDA restricted Pharma manufacturers ( here is one article, guardianlvDOTcom/2014/03/pharmaceutical-drug-plants-in-india-under-us-fda-ban/ ) and you'll find many producers like; Ranbaxy, Sun, and others. In January 2014 the FDA even found Dr. Reddy was providing contaminated and poor quality heartburn medicine Lansoprazole. I was told by a medical professional which I trust but I don't know if this is accurate or not. Drug manufacturers have up to a 20% variable in active ingredients and still meet acceptable levels. Think about it, between drug batches there could be upwards of a 40% swing. Could this in anyway skewed the AD results? I would hope that Prana is analyzing all batches of PBT2 received.

  • Reply to

    Iron in neurodeg disoders

    by pivalde 12 hours ago

    int,: "OK. I think it would be inexpensive for them to be monitoring iron and copper platelets"

    What are iron and copper platelets and how would you monitor them?

  • Reply to

    Is $2 going to hold?

    by stevelee779 Sep 18, 2014 3:48 PM

    from looking at the chart $2 has been a recent support area over the last few months, and going back a bit you can see where the 1.50 area was support. I hope we'll hold at $2 or above, but anything is possible. I'll save some $ off to the side in the event we do drop some more. I can't see adding here though, as I am already in just above this range.

  • Reply to

    Is $2 going to hold?

    by stevelee779 Sep 18, 2014 3:48 PM

    having patience is often needed with these stocks. I just wish our base from which to move up from was a bit higher. Too much of a sell off after that last news. It happens though. GLTA and have a great weekend!

  • Reply to

    Iron in neurodeg disoders

    by pivalde 12 hours ago

    OK. I think it would be inexpensive for them to be monitoring iron and copper platelets in the IMAGINE extension trial. Do you know if they are?

  • Reply to

    Iron in neurodeg disoders

    by pivalde 12 hours ago

    interestingto me, it was not so important, I took it away.

  • I found this on Hot Copper posted by Skint - there were some recent questions about how fast PBT2 could actually get to market.
    Last I saw Dr Reddy's was making the PBT2 for Prana. They look big enough to do a distribution deal with Prana without any Big Pharmas.
    Feb. 3, 2012, 6:43 a.m. EST

    Dr Reddy's Laboratories net profit soars 88%
    By Rumman Ahmed
    --Consolidated net profit at INR5.13 billion versus INR4.08 billion forecast in poll
    --Consolidated sales climb 46% to INR27.69 billion, beats INR25.19 billion poll estimate
    --Generic drugs sales in North America more than double, generic Zyprexa sales help
    --Local generic-drug sales grow 11% in third quarter
    BANGALORE (MarketWatch) -- Dr. Reddy's Laboratories Ltd. Friday reported a better-than-expected 88% rise in third-quarter consolidated net profit, led primarily by exclusive sales of a generic schizophrenia drug in the U.S. and a weak Indian rupee.
    Consolidated net profit for the quarter through December surged to INR5.13 billion from INR2.73 billion a year earlier, the generic-drug maker said. Profit topped the INR4.08 billion average of forecasts in a Dow Jones Newswires poll of 15 analysts.
    Consolidated sales climbed 46% to INR27.69 billion from INR18.99 billion, beating the INR25.19 billion poll estimate.
    The results cheered investors, pushing the company's shares 2.2% higher to INR1,670.50 at close on the Bombay Stock Exchange, outperforming the 1.0% rise in the broader market.
    The Mumbai- and New York-listed company, among India's top four generic-drug makers by sales, is benefiting as patents for several top-selling drugs expire in the West.
    Dr. Reddy's, which received more than three-fourths of its revenue from selling generic drugs globally, said sales from the segment grew 57% to INR21.29 billion.
    The biggest push for the segment's sales growth came from the U.S....

    Sentiment: Strong Buy

  • CH I wonder if they are doing this in the extension trial?

PRAN
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