Depend what type of mood I'm in. But I think that's not even a question.
Not everyone will be able to use AFREZZA, much like not everyone can use many drugs out there.
There will always be issues, but this will change things. I think people are just afraid of progression sometimes.
Sentiment: Strong Buy
What matters is if the FDA thinks cute and convenient is equal to clinical utility and worth risk to the lungs when injectable works better, or if cute and convenient should be approved over the more effective medtone at the same risk to the lungs.
Insulin needles are now 30 gauge, ie very little. Insulin is still better than afrezza. Dr. are not going to freely rx this due to fear of long term lung safety. Not enough data out there yet, it will heavily be black boxed with restrictions, added to the increase cost over insulin and this equals a failure just like exubera.
You aren' t diabetic are you? Oral medication is for type 2s. Type 1s who need insulin need something much faster acting with meals. Type 1s can't control their diabetes with oral medication. They require insulin.
You under estimate the ease with which the modern Insulin pen can be used and over estimate any discomfort associated with it's use. Virtually painless if used with a fresh needle and takes about 10 seconds..
For diabetics its not just about pain or discomfort of the actual injection. As you mentioned most pens are relatively low pain. The other issue for diabetics taking an injection is whether it can be done discreetly without other people noticing. My diabetic mother in law disappears into the bathroom before every meal whether we are at home or in public eating. She finds it quite embarassing to pull her shirt up exposing her belly and swabbing her skin first to be quite akward and embarassing as the whole world looks on. It also creeps a lot of people out who see it. Then there is always the small child at the next table who notices and yells out ,"mommy, what is that lady doing !?" But give diabetics the choice of a small whistle sized inhaler easily hidden in the palm of your hand which can be done with very little notice and they no longer have to feel strangers eyes staring at them ... they will choose the puff. It is far more convenient and far more discreet.
Sentiment: Strong Buy
How about the injection site. Not being diabetic I assume that is tender and painful for awhile? I took subQ allergy shots as a kid and NEVER liked them. Help me understand how insulin feels?
Ad inhaler takes about a second two use.
If you are seriously trying to argue that people rather inject themselves instead of puff a whistle sized inhaler, you are either short, or just clueless.
Also, can be used by type I and type II..
As mentioned .. Insulin is a $20 BILLION market, not mention oral med market.
Doesn't make any financial sense to partner. They will be paying 9-10% to Deerfield on all their debt. All you predicting $3-$5B in sales are lunatics. You think Afrezza is going to take the majority market share from Humalog and convert every patient over to the inhaler.....hahahah!