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  • dr_97701 dr_97701 Dec 16, 2010 1:22 PM Flag

    other irons in scientific fire

    1. Lanza R, et al. Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.PLoS One. 2010 Mar 24;5(3):e9838.
    "In particular, we found that these rat iPS cells could differentiate to midbrain-like dopamine neurons with a high efficiency."

    2. Lanza R, et al. alpha-Thalassemia-like globin gene expression by primitive erythrocytes derived from human embryonic stem cells. Hemoglobin. 2010 Jan;34(2):145-50.
    "unbalanced globin synthesis appears to be an inherent feature of human erythroid cells that synthesize predominantly embryonic-stage globins."
    POSSIBLE FUTURE CLINICAL APPLICATION: thalassemia and other erythropoetic disorders.

    3. Lanza R, et al. Methods Mol Biol. 2010;636:105-21.
    Directed differentiation of red blood cells from human embryonic stem cells."In this chapter, we describe a robust system that can efficiently generate large numbers of hemangioblasts from multiple hESC lines using well-defined conditions and produce functional homogeneous RBCs with oxygen-carrying capacity in large scale."

    4. Lanza R, et al. Stem Cells. 2010 Apr;28(4):704-12.
    Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. "human INDUCED pluripotential stem cells die early."
    POSSIBLE CLINICAL APPLICATION: don't used induced stem cells, use human embryonic stem cells themselves.

    5. Lanza R, et al. Stem Cells. 2009 Sep;27(9):2126-35.
    Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration.
    "Here we show long-term functional rescue using hESC-derived RPE in both the RCS rat and Elov14 mouse, which are animal models of retinal degeneration and Stargardt, respectively. hESC-RPE survived subretinal transplantation in RCS rats for prolonged periods (>220 days). The cells sustained visual function and photoreceptor integrity in a dose-dependent fashion without teratoma formation or untoward pathological reactions. Near-normal functional measurements were recorded at >60 days survival in RCS rats. In NIH III immune-deficient mouse model, long-term data (spanning the life of the animals) showed no gross or microscopic evidence of teratoma/tumor formation after subretinal hESC-RPE transplantation. These results suggest that hESCs could serve as a potentially safe and inexhaustible source of RPE for the efficacious treatment of a range of retinal degenerative diseases.
    CLINICAL APPLICATION: Stargardt and adult MD. (using hESC derived RPE cells, not induced RPE cells.)

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