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  • rwidness rwidness Jan 30, 2012 4:54 PM Flag

    Evidence of Enduring Engraftment?

    What is the strongest evidence out there that would increase our confidence that ACTC stem cells engrafted in humans are likely to achieve long-term healing? Is it mostly evidence extrapolated from animal research? What, if anything, from other human stem cell treatments bolsters the idea of long-lasting engraftment? I'd be interested in statements or opinions anyone has come up with.

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    • BUMPing to TOP!

    • POST to the TOP!

    • The VOTE is IN! EnGrafting is taking HOLD!

    • BUMP!

    • Best thread on this MB in a while! Thanks. AND its even better with Pussons on ignore. However, I'd love to know Ms. Freeman's current eyesight status. Maybe we can get an answer to this during the Conference Call. I'd really like to know why the cells didn't migrate and graft for her, but they did with the Stargart's patient. Is her failure to comply with her immunosuppressant regimen the sole reason? Hope so.

    • Opinions welcome...

    • Bump to the TOP!

    • That's all we've got. If we think about Lanza's writings, that may be all there is in the universe for us that we can know... or "know".

      By the way, I've been thinking about that placebo effect notion, which, by the way, they decided it WAS NOT... in that article. I was joking a bit there.

      I think we will have to see if more cells have an impact; we will have to see if there is some limited rejection that may require addressing; and lastly we may see that biologically active factors, like "growth factors" referenced in the RPE animal studies, also could be a part of what is improving the sight of the patients.

      It will be interesting to see, but I think that we can't know exactly how it will play out, but the results, as with the animal studies, are still consistent and encouraging for use to improve the condition and lives of these patients in a substantial and meaningful way.

    • If you care to read the Lancet report. i believe teh Discussion section on page 7 states thet do not know if the observed improvement in teh Stargardts patient resulted from the RPE cells the Immunosupresant drugs administered to this patient or placebo affect.

      So before you get Tooooo Excited you really should read the clinicals trails report.

      • 3 Replies to dhparsonsjr1
      • I just read the discussion on page 7 of Lancet report. I think you just want to satisfy your ego and try and prove that the engraftement is not working. Here is and extract from the report dsicussion. I don't see any issues.
        <Our findings suggest that transplanted hESC-RPE cells in the patient with Stargardt’s macular dystrophy attached to Bruch’s membrane and persisted for the duration of our observation period. >

        <Our study is designed to test the safety and tolerability of hESC-RPE in patients with advanced-stage Stargardt’s macular dystrophy and dry age-related macular degeneration. So far, the cells seem to have transplanted into both patients without abnormal proliferation, teratoma formation, graft rejection, or other untoward pathological reactions or safety signals. Continued follow-up and further study is needed. The ultimate therapeutic goal will be to treat patients earlier in the disease processes, potentially increasing the likelihood of photoreceptor and central visual rescue.>

      • Oh, come on dh, are you really that stupid? Before I flush you down into the ignore (septic) tank, BEHOLD:

        Anatomic evidence of successful stem cell derived RPE transplantation was observed clinically and with high resolution imaging technology in the patient with SMD. This evidence included increasing pigmentation at the level of RPE, within the area of the transplant, beginning one week after transplantation and throughout the follow-up period. Transplanted stem cell derived RPE appeared to engraft in the proper location and assume normal RPE morphology. Engraftment and increasing pigmentation were not detected in the dry AMD patient.


      • I don't buy off on this placibo effect crap. It is one thing for a patient to mentally think they feel better from an inert pill and another for someone to actually experience an improvement in sight that is physically measured!

    • There is evidence of RPE cells survived in the stagardts patient for at least 6 months... as shown and discussed in the lancet article. 6 months is a long time for transplanted cells to survive anywhere... similar to fat transplants in cosmetic procedures. More cells may survive if they tranplant larger quantities like they plan for the next 10 patients.

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