Would the platelets be stored at the hospitals or would they be manufactured at the hospital?
It makes sense to make them on sight at multi locations.
Is there a medical device maker type company needed to help achieve sucess in the long run?
ACTC is working with the Langer lab making a Bioreactor that will be on-site. ACTC will send the cryo- preserved pre-platelets (megakaryocytes) where they can be thawed and stimulated to turn into platelets "on-demand." This solves the whole 3-5 day shelf life issue with plateletes, and provides hospitals, blood banks, etc with a ready to go off-the-shelf infinite supply of platelets. And platelets will just be the start. How's that for "wicked big!"
But the literature also says Megakaryocytes are directly responsible for producing platelets which are needed for the formation of a thrombus, or blood clots. How are these problems avoided? It’s one thing to whip up some megakaryocytes but another to insure they do –Only—what you want!! There are several diseases which are directly attributable to megakaryocyte function or abnormal platelet function. Ironically, having platelet counts above 1,000,000 platelets/μL can lead to hemorrhagic events. Is the turn off switch reliable?
I believe they will make a final product, and possibly also produce a facility capability for distributed manufacture on demand, if they decide that is helpful either with distribution or as a business model and they have a product that works from both a manufacturing AND business model perspective.