I found evidence of the first SMD patient improvement was well documented!
Patient went from 20/800 and no letters reading ability to 20/500 and 15 letters at one year!
Anyone seen this before?
Neither of the first patients lost any vision after treatment!
Sentiment: Strong Buy
First two patients were injected on 7/12/2011 at UCLA, Los Angeles during the summer, which can get hot. Temperature may be one of the key factors in embryonic cell growth and development, as higher animals incubate their eggs and fetuses in higher temperatures than their ambient surrounding temperatures. Birds and hens sit on their eggs to keep the cells in the eggs hot. Human's keep the fetus developing in womb temperatures of at least 98.6 degrees F, which is considered hot weather temperature. The body builds fevers above 98.6F during infections to get white blood stem cells producing in high gear.
Re: ........ the first SMD patient improvement was well documented!
Patient went from 20/800 and no letters reading ability to 20/500 and 15 letters at one year!......
Achtung, achtung! Inform family and friends........ don't let them miss the ACTC boat, bus, plane or train.
Soon, real soon......... ACTC sheeples will be eating their favorite garden vegetable with steak !
FIGHTERPILOT • May 11, 2011 12:57 PM
Those times are gone and below .30 will not last that much longer. NO BRAINER
Anticipation alone will drive the SP higher. Anticipation of a game changer. Just picture this:
With every patient, results can be seen in a short time, if the results are positive, overwhelming evidence will accumulate rapidly and lead to FDA approval speed you never have seen before.
These are open trials !!!!!! Open trials with results under a microscope. Compare with seeds in your garden, when the plant breaks through the soil and is growing to your favorite vegetable you have with your steak, only totally derailed bashers, super idiots, like the ones we have on this MB, will call this a failure. Bashers are toast !!!! No Brainer !!!!!
Here is the part about the SMD patient going to 15 Letters!!
0010| As further described below, the visual acuity of the Stargardt's patient improved from hand motions only to 20/800 vision. Before treatment, the patient was unable to read any letter on the ETDRS visual acuity chart. However, by two weeks posttransplantation, she was able to start reading letters, which improved to five letters at one to three months and 15 letters at one year in the treated eye (20/500 vision).
This does seem to suggest the progress continues for a year!!!
This part is very exciting!
100100] Controlled hESC differentiation resulted in near- 100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. Visual measures showed signs of improvement during the first two months. At 2 weeks, best corrected visual acuity (BCVA) had improved from 20/500 pre-treatment to 20/200 in the stud eye of the AMD patient, and continued to show improvement (20/200-20/320) and an increase in letters on the Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity chart. The SMD patient improved from hand motion to counting fingers during the same period; by month 1 and 2 BCVA improved to 20/800. Before RPE transplantation, the patient was unable to read any letters on the ETDRS chart, but began reading letters at 2 weeks, which continued to improve during the study period (5 letters at 1 and 2 months).
This is some very goodnews indeed!!!
I wonder how much better the news is going to be with the Cohort 2a folks!!!
Remember they already have that information and look at what they are saying about what they expect with the patients at the earlier stages!
This disclosure provides the first description of hESC-derived cells transplanted into human patients. Results are reported for one patient with each of Stargardt's Macular Dystrophy (SMD) and Dry Age-Related Macular Degeneration (AMD). Controlled hESC differentiation resulted in near-100% pure RPE populations. Immediately after surgery, hyperpigmentation was visible at the transplant site in both patients, with subsequent evidence the cells had attached and integrated into the native RPE layer. No signs of inflammation or hyperproliferation were observed. The hESC-derived RPE cells have shown no signs of rejection or tumorigenicity at the time of this report. Visual measurements suggest improvement in both patients. Where did you get that verbage?