For a lack of a better word opk share holders own technology, in other words patents. I am not going to post links and do your research for you. Without Frost, the company still owns those technologies and has other brilliant minds in place. Their technology to strip the shell off of a protein is huge. I cannot even begin to explain the potential there. Simply put though, viruses mutate, so anyone medication shortly becomes useless. This technology makes a medication that once administered, it will make one immune from the mutations that a virus might make and the illness it might cause. Think universal flu vaccine. Think h1n1 and it's mutations. Is this particular technology at phase 3 yet? No. At least one other unrelated technology is in phase 3. If Frost quit the company tomorrow, as long as the technology remains there, opko will get a lot of drugs to level 3 in the next 5-10 years, some will be blockbusters. That is all of the research I am doing for you.