If you listened closely it was a positive call. He did not just blurt take profits, he said if you got in between 3-4 a share, which means you are up 70% - 120%, he said sell 25%. In Cramer world he NORMALLY says sell half on a double. He also said he has faith in Dr. Frost and he thinks 2013 will be a very good year for opk. I am not defending Cramer, he has his method of investing. He might be a complete jerk, however, for all the ups and downs in his career he still has a net worth north of 100 m. I do not. So he is worth a listen if you understand his methodology, then make your decisions based on his tendencies. He kept pounding DF a couple years ago saying sell at an all time low, thanks Jim, It more than doubled for me.