The upward momentum has increased even further. The volumes over the last few days have been extremely high. Nearly 29 million shares have been traded in the last two days, and some consider this part of a short squeeze. There were 35 million shares (22% of the float) short on September 30, and the price on that date was $8.81. So the stock has moved nearly 40% over the last couple of weeks. The announcement about investment in Zebra Biologics has increased the excitement, and even Dr. Frost has continued to acquire shares consistently, though in small quantities. As mentioned in an article on SA, people are skeptical about whether the announcement of Zebra Biologics actually played a significant role in the move. The undisclosed investment appears to be speculative as Zebra is into development of next generation antibodies. It may take years before this technology can be commercialized to contribute meaningfully to OPKO's top or bottom line. So ultimately, this move can be traced to the power of Dr. Frost. Frost now controls more than 152 million shares of OPKO Health out of the outstanding 403.6 million shares (37.7%). His investment in Biozone Pharmaceuticals (BZNE), which owns the high potential drug delivery technology QuSomes, and the agreement between OPKO and Biozone, has made a lot of news. The acquisition of PROLOR Biotech, and several other investments over the last couple of years have helped the stock post remarkable gains. Again, many of these investments may take time to help improve the financial position of the company. The valuations are surely exceptionally high. The price to sales is nearly 50, and the price to book is also extremely high. For those who want to invest on valuations, it is not so convincing. However, if the squeeze gets tighter, then it is possible for the stock to go even higher.