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Pernix Therapeutics Holdings, Inc. Message Board

  • rick449 rick449 Mar 1, 2013 3:08 PM Flag

    VITUZ vs Tussinex

    How do you think VITUZ will compete with Tussinex? I can't find the dosage info anywhere on VITUZ.

    Seems that if it's priced cheap enough docs may prescribe that over Tussinex. Personally I think Tussinex is #$%$. Doesn't work for me. When I get sick I like to "feel" the hydrocodone working. Can't stand that time release suspension.

    But I'd like to know the dose for VITUZ. Just can't find it.

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    • VITUZ is an immediate-release product; Tussionex (and its 2 generic equivalents) are extended-release. On the whole, docs much prefer extended-release products, b/c of the convenience, therefore, patient compliance is better. Several years ago the FDA pulled all un-approved Hydrocodone cough medicines from the market. If memory serves, Zyber Pharma (Pernix's predecessor company) had some unapproved HC products on the market that had to go. This FDA action gave a huge boost to UCB's Tussionex and the one or two old immediate-release HC products that had approvals. Several labs began aggressively pursuing generics for Tussionex, and a couple of them landed approvals back in 2010/2011 timeframe. This has made the cost of the extended-release product much more palatable, so there is no cost-related reasons for a doc to prescribe an immediate-release product at all.

      The VITUZ filing was initiated by Cypress - the company Pernix bought late last year. Cypress is a generic player. However, there are no equivalents to the VITUZ formulation (5mg HC/4mg Chlorpheniramine). That means Pernix would need to market this as a branded product through their sales force. It will be tough sledding to gain market share against Tussionex and its generics. Brand is too entrenched, and the extended-release benefits are key for the docs. IMHO, this is why the market did not respond at all to the announcement yesterday.

    • I will try to look up after the close. I am watching a couple others that seem wounded. I will let you know on the weekend, maybe on the other board.

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