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BioCryst Pharmaceuticals, Inc. Message Board

  • nsd870 nsd870 Nov 7, 2012 8:39 PM Flag

    Peramivir news - just out tonight

    "“We are proceeding with a full analysis of unblinded data from the trial, and a final decision will be made following completion of the analysis and further discussions with our development partners; however, it is unlikely that peramivir development for US registration will continue.”

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    • OMG

    • So the CDC testing in 2009 showing Peramivir 5-10X more potent than Tamiflu. cdc.g*v/mmwr/preview/mmwrhtml/mm58d0428a1.htm
      Hmm.. govt. as a customer? Run from them. This makes the HHS/CDC expense into what?

      Maybe Shionogi will want to sell it in ROW. According to their tests.. it's more effective than Tamiflu.. aac.asm.o*g/content/55/11/5267.abstract

      Peramivir is an investigational influenza neuraminidase (NA) inhibitor, in the same class as the approved flu drugs oseltamivir and zanamivir (Relenza). ...
      In the first study, researchers from Shionogi and Co. in Japan investigated the inhibitory effect of peramivir against avian (bird) influenza viruses both in vitro and in vivo. In laboratory cell cultures and in mice, peramivir strong inhibited neuraminidase activity and replication of various highly pathogenic bird flu strains.

      The therapeutic effect after a single dose of peramivir was comparable to that of repeated doses of oseltamivir or zanamivir for 5 days; when peramivir was given for 5 days, its effectiveness was greater than that of the other 2 drugs used for the same duration. hivandhepatitis.c*om/2009icr/icaac/docs/092209_e.html

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