Bloomberg story out of Japan, at 10 Eastern.
A gene mutation known to help influenza resist Tamiflu was found in the first of three H7N9 bird-flu patient specimens in China, sequence data show.
The flu virus from the patient in Shanghai has a mutation known as R292K that causes high-level resistance to the Roche Holding AG (ROG) pill and reduced sensitivity to a related drug from GlaxoSmithKline Plc (GSK) called Relenza, genetic sequence information posted on the website of the Global Initiative on Sharing Avian Influenza Data show. Subsequent H7N9 specimens from a patient in Shanghai and one in Anhui province don’t show the mutation.
Right, because tamiflu doesn't dock to the neuraminidase as effectively as Relenza, and apparently Peramivir - so those millions of doses of tamiflu might not be so useful
The latest study on Tamiflu resistance in actual treatment with H5N1 patients is more concerning. N Engl J Med 353: 2667-2672 Two patients died after Tamiflu treatment and had highly resistant virus isolated from them. Concerningly, one patient recieved higher than normal doses of Tamiflu within 48 hours of getting sick, but still died. The structure of the neuraminidase inhibitor in Tamiflu is not as good a fit as the structure of Relenza and seems more prone to allowing resistance to develop. It was thought that resistant H5N1 would be less pathogenic, but the deaths of Tamiflu treated patients with H5N1 suggest this may not be the case.