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Affymax, Inc. (AFFY) Message Board

  • niepmln niepmln Sep 2, 2013 9:52 PM Flag

    Question for grey (other shorts feel free to chime in)

    In my last posting you mentioned that I could not handle the truth about Takeda not being able to explain the hypersensitivity reactions. Lets remember that these were anaphylactoid and not IgE mediated anaphylactic reactions. Translation-non immune anaphylaxis. It's not like these patients experienced acute hepatotoxicity from toxic metabolites. IV drug administration carries a larger risk than other routes of administration for anaphylactoid reactions. Some thoughts are that sudden vasodilation can cause mast cell degranulation. For example: vitamin K, Iron, and recombinant DNA human insulin have all been reported to cause anaphylactoid reactions in some patients. It's pretty certain that vitamin k, Iron, or insulin are not harmful substances. There are even idiopathic anaphylactoid reactions that are unexplained. Talk to any anesthesiologist and they will tell you that some drugs you can push through a patient quick and some, such as vancomycin, although safe for the patient, if pushed through too fast could still kill the patient. Also would like to know why naproxen sodium (Aleve) is still on the market, as of Aug 31st of this year, 3193 adverse reactions have occurred and 26 of those where anaphylactic (.81%). All of those could have lead to death if untreated and there are many other NSAIDs on the market, why is Aleve still on the market when more of the population is exposed to it than OMONTYS? The deaths associated with dialysis alone increases the side effects that include death. Transfusions of matching whole blood products can cause anaphylactoid reactions as well. My point is that Takeda has taken the responsible action to look into why anaphylactoid reactions occurred. Changing the route of administration to subcutaneous or recommending an antihistamine in conjunction with the first IV drug administration could solve the issue.

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