Not the longs. Definitely not shareholders. There is no difference for between Friday Oct 18 and Tuesday Oct 22. They are just awaiting Takeda's decision whenever it happens. However, if you've hedged your short position by buying Oct calls there is a huge difference. Friday you've got nothing to fear. Monday you're exposed to huge losses with expiration behind you.
How does that work. If shorts allow the price to rise to $2.05 then their broker exercises the options for them.
But if the stock closes below $2 on Friday the contract will expire worthless and the hedge is gone.
If you are long the stock you are waiting for Takeda's decision. That is the only date you need be concerned about. And you can only lose what you put in.
For the shorts the potential lose is as high as the stock goes unless they purchased call options.
Oct call owners can purchase shares through the third week of Oct at the strike price regardless of the price of the stock. For shorts its protection from a sharp increase but it has an end date.
The price protection ends Oct21.