A neighbor bought the Ford Fusion hybrid a few years ago, and loves it. He had bought Asian-branded cars before that, so it was a bold change for him. The Titanium hybrid version of the Fusion has been so popular dealers sometimes have trouble keeping them in stock, so it might pay to visit or call multiple Ford dealers to see if you can can test drive one of those. The SE version has a different interior, so try to compare those.
With any hybrid, people get different mpg results depending on how they drive, so be sure to ask about driving strategies (speed, braking style, etc). Our neighbor made a game out of teaching himself added tricks, enjoyed the learning process.