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  • cmon_early_retirement cmon_early_retirement Jan 23, 2006 11:18 AM Flag

    Abstract from meeting :

    Differentiation of Human Embryonic Stem Cells to Insulin Producing Cell Clusters
    Anish S. Majumdar, Ph.D. Senior Director, Immunology, Geron Corporation, Menlo Park, CA

    "Recent success in cadaveric islet transplantation for patients with type I diabetes has increased interest in discovering an alternative source of stem cells with potential to differentiate into pancreatic ? cells. Human embryonic stem cells (hESCs), which are immortal and capable of both self-renewal and differentiation, could be used for this purpose. We have developed a three-stage differentiation protocol in which human embryonic stem cells (hESCs) are allowed to differentiate to definitive endoderm. In the presence of selective growth factors, extracellular matrix and maturation inducing factors, the pancreatic component of the endoderm differentiates into insulin and glucagon expressing islet-like cell clusters. These clusters, similar to human islets, secrete C-peptide in response to glucose challenge. In vitro and in vivo properties of these islet-like cells derived from hESCs will be discussed at the meeting."

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