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Geron Corporation Message Board

  • earfool earfool Nov 27, 2012 8:25 AM Flag


    Thanks to those who brought this information about the new clinical trial for Imetelstat to the Geron message board. (Where was the PR from Geron?)

    I was unfamiliar with Myelofibrosis so here is a brief definition cobbled together from a few sources.

    “Myelofibrosis is a type of chronic leukemia — a cancer that affects the blood-forming tissues in the body. Myelofibrosis can occur on its own (primary myelofibrosis) or it can occur as a result of another bone marrow disorder (secondary myelofibrosis). It is a serious bone marrow disorder that disrupts your body's normal production of blood cells. The result is extensive scarring in your bone marrow, leading to severe anemia, weakness, fatigue, and often, an enlarged spleen and liver.”

    According to Ayalew Tefferi MD survival is about 6 years and there is significant degradation of quality of life including amimia with spleen and liver enlargement.

    You can get an impression of Dr. Tefferi by doing a search on You Tube and viewing his video on past studies of Myelofibrosis done in 2008. He has done several clinical trials agents to treat this disease and at least one is now approved by the FDA.

    The fact that he is now looking at Geron’s Imetelstat is mildly encouraging. I still wonder why Geron never disseminates this type of Good News to its common share investors. Is there some type of FDA regulation against that or is it that Geron management simply has distain for us?


    Sentiment: Hold

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    • Question to Anna: What is Geron's involvement with this study?
      Answer from Anna: This is an Investigator Sponsored Study (IST) that has opened to enrollment at the Mayo Clinic using imetelstat in patients with myelofibrosis.

      Typical non-informative response from the Dr. No super secret spy organization.

      • 1 Reply to skezqn
      • Thanks ....based on your question to Anna I looked up IST and

        Generally, Clinical trials can be divided into two groups, according to the type of Sponsor:

        The typical industry-sponsored clinical trial, where the trial is conducted by a private entity Geron

        The Investigator Sponsored Trial where the Sponsor is a physical person (physician, nurse, dentist, or other health professional) or a "not-for-profit organization", which can be a governmental body, a public institution, or a research group..... like the Mayo Clinic study.

        The (Spector) of transparency continues to plague Geron investors.

        Sentiment: Hold

    • Anna should be replaced by someone who can talk the language of Wall Street. We do not need a PHD who does not know the Street and Main Street.

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