in the abstract. This is causing a sell off. I think this is moot. If it works on bone marrow and blood and report claims CR or PR. No way in hell it doesn't reduce spleen size. Even if it doesn't, it could be used in combination with JAKs which reduces spleen size (treating the symptom,not the cause).
AF is a manufactured entity owned by jimmy's hedge fund buddies who manipulate anything they get their hands on. Its Jimmy the #$%$ on TV with AF his henchman on the biotechs. Someday, there game will be over, they post on this site often. Probably ended today for them on this one but "make no mistake" these flammers will move to another stock to manipulate as long as they have the cover of the media.
Since spleen enlargement is a symptom of a progressing disease I'll assume that Imetelstat will be given early in the disease development, stopping the disease itself and with it its related symptoms, including an enlarging spleen. So no I don't see the issue of spleen size being a problem going forward.