Here's a simple thought. Last year - ARNA (Arena Pharma) with only 1 questionable weight loss drug in the pipeline rose 6 fold from $2 up to $$12+ prior to approval giving the company a market cap well over 2 Billion at that time. Ampio which has more than 1 potential blockbuster drug is far too cheap at this price. If AMPE rose the equivalent of ARNA, with an equal market cap it would trade north of $50.... The shorts are in for a rude awakening soon. I would not want to be short this stock as your max gain is $6 but your loss could be unlimited. With 4.5 million shares short and a very small stock float, investors will be tripping over themselves to cover.