less 0 C what happens to the drug? When the drug is returned to 15 C, what's the remaining active yield? Is it 60-90? If so, you can trend the results and build off of STEP to see what predicted would be. Not a total disaster considering we know what the multiple injections studies reductions are. Physicians will only be looking to the multiple injections for their patients. AMPE already stated that the FDA is willing to examine the STEP study (I suspect they looked at stability data) and were still fine with the trial. I expect STEP to be slightly lower than SPRING results but with the caveat of temperature affecting the % of actives given to patients.