Nice point on alternative uses for Dacogen. If I can reflect on this point the $250M U.S. estimate is for MDS,AML CML. As we get alternative uses for Dacogen this estimate will increase and WW will also increase 2X-3X. If you look at clinicals on Dacogen, the biggest news would be in solid tumors, those trial's have started. The other areas will be to act as a mainteances drug in patients that are in remission with several different cancers (continued therapy). The (ALL) news is all new and the reaction looks like street will like it.