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Astex Pharmaceuticals, Inc. Message Board

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  • maximus06906 maximus06906 Oct 14, 2008 9:53 AM Flag

    IR response


    What is PK/PD? Also, does this mean that MP-470 is not a viable drug as a stand alone compound and needs to be combined with other compounds to move forward?


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    • Pk/PD is used to measure how much of the drug is in the blood. If you increase the mg, you would expect a increase of the drug in the blood stream. But they're not seeing that as a single agent. It means that the body only absorbs some of the drug. They had one response as a single agent and several in combination. On Oct 21-24, supg will present data at Eortc-Nci cancer conference from the ph1b.

      Combination seems to be the best direction, mp-470 inhibits several pathways and with the low tox, is a perfect combination drug.

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