Pk/PD is used to measure how much of the drug is in the blood. If you increase the mg, you would expect a increase of the drug in the blood stream. But they're not seeing that as a single agent. It means that the body only absorbs some of the drug. They had one response as a single agent and several in combination. On Oct 21-24, supg will present data at Eortc-Nci cancer conference from the ph1b.
Combination seems to be the best direction, mp-470 inhibits several pathways and with the low tox, is a perfect combination drug.