Ash had some good things. First dacogen works for 8 hours, the half life is 4x dacogens,they are seeing improved PK profile over dacogen with sgi-110.
The AE's are reporting is superior to dacogen 85% of dacogen pts suffer to lower platelet counts after taking the drug. SGI-110 only 8%. I think strong platelet counts is a good thing.
With dacogen 87% see a immunosuppressed and risk infections, with sgi-110 this drops to 27% of pts.
I believe a strong immune system is a good thing. This way sgi-110 doesn't have to do all the work. Vidaza AE's are even greater than dacogens, so this may point at a better drug than Vidaza? We'll have to see.
Free, you think that Vidaza outsells Dac in US because of a better marketing team at Celgene or another reason? Reason I ask is because of the comment about Vidaza where you say it has greater AE's than Dac. Market share has been the same for the last 3/4 years from what I remember.