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Astex Pharmaceuticals, Inc. Message Board

  • weightbayou weightbayou May 9, 2013 12:33 AM Flag

    Astex awarded important patent this week.

    United States Patent 8,435,970
    Curry , et al. May 7, 2013

    --------------------------------------------------------------------------------
    Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyra- zol-4-yl]-urea

    Abstract
    The invention provides combinations of an ancillary compound and a compound which is a salt of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyra- zol-4-yl]-urea selected from the lactate and citrate salts and mixtures thereof. Also provided are crystalline forms of the salts, methods for making the salts and their uses in treating cancers. The invention further provides combinations of an ancillary compound and a compound of the formula (I) as defined in PCT/GB2004/002824 (WO 2005/002552) or a compound of the formula (I') ##STR00001## or a salt, solvate, tautomer or N-oxide thereof, wherein R.sup.1, E, A and M are as defined in the claims.

    --------------------------------------------------------------------------------
    Inventors: Curry; Jayne Elizabeth (Cambridge, GB), Gallagher; Neil James (Basel, CH), Lyons; John Francis (London, GB), Thompson; Neil Thomas (Cambridge, GB)
    Applicant: Name City State Country Type

    Curry; Jayne Elizabeth
    Gallagher; Neil James
    Lyons; John Francis
    Thompson; Neil Thomas
    Cambridge
    Basel
    London
    Cambridge
    N/A
    N/A
    N/A
    N/A
    GB
    CH
    GB
    GB

    Assignee: Astex Therapeutics Limited (Cambridge, GB)

    Appl. No.: 12/306,479
    Filed: June 29, 2007

    Sentiment: Strong Buy

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