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Astex Pharmaceuticals, Inc. Message Board

  • michaelplongo michaelplongo May 24, 2013 3:37 PM Flag

    Abstract Submission EHA18ABSSUB-3339 OUTCOMES OF INTERMEDIATE OR HIGH RISK MYELODYSPLASTIC SYNDROMES (MDS) PATIENTS POST AZACITIDINE AND/OR DECITABINE TREATMENT FAILURES WITH SGI-110, A NOVEL SECOND GENERATION HYPOMETHYLATING AGENT (HMA)

    Results: Fifteen patients with Intermediate-1 (3), Intermediate-2 (5), High Risk (6) MDS and 1 with CMML, … were enrolled. All patients enrolled (100%) had prior treatment with decitabine and/or azacitidine; 87% had prior azacitidine, 53% had prior decitabine, and 40% had both azacitidine and decitabine as prior treatment2Responses were observed in 5 patients for an overall response rate of 33% with reported response duration of 28–224 days. Details of each of the 5 responders are shown in Table 1. The median bone marrow blast count at baseline for the responders was 16.5% while the non-responders were 5%. Median LINE1 demethylation in responders showed a decrease by -19.3% compared to -12.0% in non-responders.

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