Mina Bissell -- extra cellular matrx. Also: Even pressure can slow breast cancer
I have been reading and watching information on the extracellular makeup (google mina bissell), of which hyuralonan is a component, along with other things like collagen.
Of course, Halozyme makes hyuralonidase which temporarily breaks down hyuralonan.
I think we are going to find that Halozyme's product is even more critical than we previously knew.
Mina Bissell proved that even if one has the oncogene for cancer, and even if that oncogene ultimately expresses itself as cancer, by changing the extracellular balance, say by reducing the percentage of collagen, you can, if this is a factor the tumor cell is using inside of it, revert cancer cells to normal cells by changing their environment within the extracellular makeup. This has to do with physical architectual surroundings of the cell inside the matrix, as well as the chemicals the tumor uses to grow.
To further demonstrate this, scientists at her lab in Berkley simply changed the extracellular matrix pressure surrounding the cells and #$%$ cancer. (Google it).
If the cells react to their environment (breast cells do not become foot cells if they are in a breast cell matrix), the cancer cells, even though they have the oncogene, do not become cancerous if their matrix does not instruct or allow them to express. In other words phenotype trumps genotype.
Applying this to Halozyme, Halozyme's products may, in the near future, not only be used to break through the extracellular matrix to deliver drugs to the cells more efficiently, but it could be used to deliver extracellular matrix drugs or components efficiently throughout the extracellular matrix to change its component ratio.
Back to pressure. Since pressure reduction and structure deformation can also allow breast cancer to proliferate, I am hypothesizing, that it may be found increasing the patient's own breast cells and thus pressure (see company Cytori stem cells used to make breast cells) may in fact also be used to decrease cancer.
If you think about this from a philosophical view, extrapolation of Mina Bissell's research indicates that the cure for cancer may not be killing it, but instead helping cancerous cells revert to their normal function by changing their environment into a normalized situation.
Think of this relationship as comparing it to to people and wars. Sylvester Stallone once said a line in one of his silly violent movies to the "villain.": "You are the cancer, and I am the cure," and then he killed the guy.
If it turns out we can keep cells from expressing their cancerous sides by modifying their extra-cellular neighborhood (matrix), then maybe it explains why people often only change behaviors (like gang activity, drug use and other criminal activity) if they change their environment to a different location.
Take it one step further, and maybe the earth will only revert to a healthy condition if its extraterrestrial environment -- water and atmosphere -- are placed back into balance.
In other words, as reduced pressure within the breast can in some case provide the environment for cancer to flourish, returning a breast to its original form and internal pressure (with the patients own normal breast cells multiplied outside the body through methods like cytori uses) then a young looking and feeling breast (no I'm not being perverted), may also reduce and in some cases revert breast cancer expression.