Hyal. blocks Antithrombin so it helps clot- PegpH20 depletes Hyal. SO it should block Clots- Data Doesn't Jibe
Inhibition of antithrombin by hyaluronic acid may be involved in
the pathogenesis of rheumatoid arthritis
Thrombin is a key factor in the stimulation of fibrin deposition,
angiogenesis, proinflammatory processes, and proliferation of
fibroblast-like cells. Abnormalities in these processes are
primary features of rheumatoid arthritis (RA) in synovial tissues.
Tissue destruction in joints causes the accumulation of large
quantities of free hyaluronic acid (HA) in RA synovial fluid. The
present study was conducted to investigate the effects of HA
and several other glycosaminoglycans on antithrombin, a
plasma inhibitor of thrombin. Various glycosaminoglycans,
including HA, chondroitin sulfate, keratan sulfate, heparin, and
heparan, were incubated with human antithrombin III in vitro. The
residual activity of antithrombin was determined using a
thrombin-specific chromogenic assay. HA concentrations
ranging from 250 to 1000 μg/ml significantly blocked the ability
of antithrombin to inhibit thrombin in the presence of Ca2+ or
Fe3+, and chondroitin A, B and C also reduced this ability under
the same conditions but to a lesser extent. Our study suggests
that the high concentration of free HA in RA synovium may block
antithrombin locally, thereby deregulating thrombin activity to
drive the pathogenic process of RA under physiological
conditions. The study also helps to explain why RA occurs and
develops in joint tissue, because the inflamed RA synovium is
uniquely rich in free HA along with extracellular matrix
degeneration. Our findings are consistent with those of others
regarding increased coagulation activity in RA synovium
If this turns out to be a significant safety issue, could they try again vs. pancreatic cancer with a different regimen or use an anticlotting drug concurrently? The world needs a treatment for pancreatic cancer.
Congrats to those who bought below 8. I have made a ton of money (with some luck) on this stock, buying before the original Roche partnership, selling, buying after the end of the Viropharma partnership, selling after that bounce, and then adding significantly in the 7s, selling half at 17 or so. Holding firm today.
My general thesis on this stock has been that HALO offers one of the very best new drug delivery technologies for biologics. Half of new big Pharma R&D is currently going into Biologics.
(Edward Roche, President Freedom Mountain Investments, former Director Science and Technology, Johnson & Johnson)
Wrong. Christ, this is so wrong it's embarrassing.
That would only be the case if the patients presented with clots pre-treatment that were CAUSED by HA. They're obviously not seeing as the patients came in and saw an INCREASE in clots post-treatment. What was the variable changed from pre- to post-treatment? Very good Fezzy, the introduction of Peg dosing!
Understand how to analyze proper causality. Clots occur for a variety of reasons, one of them appearing to be exacerbated by Peg treatment.
If your posts were aimed less at discrediting another poster (notice: "less") and more at the value of PEG ( i.e. "Terrific", or "interesting, but with the following doubts", or "not promising, because...", or "junk science") then they would be of greater value and less prone to be viewed as another effort to influence stock movement. Yes, I know, you are not interested in your message board image. It was only a suggestion...
This battle between you and fezz is getting old quick. Take it easy on the swearing. It's unbecoming of an oncologist. How about an analysis of the situation and an educated guess as to what is happening physiologically?