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Halozyme Therapeutics, Inc. Message Board

  • fezziwig2008 fezziwig2008 May 1, 2014 12:53 AM Flag

    Peg Needed Significant Steroid Dose in Ph1b to reduce Adv Effects- Abraxane Prevents Use in Ph2


    The facts behind this stock have changed or at least emerged- I am partially at fault for missing two crucial pieces of evidence on the ESMO poster- were you aware of the CVA death or the fact that in Ph1b patients were given 8 mg of Dexamethasone 8-12 hrs before and after taking peg? I wasn't- Why were they given this medication? To reduce the side effects of PEG- which I thought were minimal- bruising etc- nope - Dexameth helps prevent clotting via antithrombin potentiation- but can't be used with Abraxane, because it stimulates cytochrome CYP2C8- which in turn strenthens the Abraxane effect. So, Peg more likely to cause CVA because of study design. Did you know that 3 months ago? I didn't. You want me to keep that quiet? Sorry- I posted what I considered the truth before, and I am still doing so . Sorry if you only like the truth when it makes you money.

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    • Dexamethasone is a corticosteroid that is used in combination with many cancer treatments to reduce inflammation, help prevent nausea, a prevent allergic reactions.
      Fezz you are the worst kind of troll by trying to suck in the uneducated to believe whatever side of the trade you are on. Take a hike.

    • Fezz is acting like a psycho.

    • The dexamethasone was administered in order "to help minimize or prevent muscle and/or joint pain that may be caused by PEGPH20." See

      Also, not sure about your conclusory statement that Dexamethasone cannot be used with Abraxane. I read Abraxane's entire label, and the following is the only mention of a potential adverse interaction with Dexamethasone (note the distinction between in vitro and what occurs in real life, in vivo):

      "In vitro, the metabolism of paclitaxel to 6α-hydroxypaclitaxel was inhibited by a number of agents (ketoconazole, verapamil, diazepam, quinidine, dexamethasone, cyclosporin, teniposide, etoposide, and vincristine), but the concentrations used exceeded those found in vivo following normal therapeutic doses."

      You seem to be drawing a lot of dire inferences without a sufficient knowledge base.

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