Peg Needed Significant Steroid Dose in Ph1b to reduce Adv Effects- Abraxane Prevents Use in Ph2
The facts behind this stock have changed or at least emerged- I am partially at fault for missing two crucial pieces of evidence on the ESMO poster- were you aware of the CVA death or the fact that in Ph1b patients were given 8 mg of Dexamethasone 8-12 hrs before and after taking peg? I wasn't- Why were they given this medication? To reduce the side effects of PEG- which I thought were minimal- bruising etc- nope - Dexameth helps prevent clotting via antithrombin potentiation- but can't be used with Abraxane, because it stimulates cytochrome CYP2C8- which in turn strenthens the Abraxane effect. So, Peg more likely to cause CVA because of study design. Did you know that 3 months ago? I didn't. You want me to keep that quiet? Sorry- I posted what I considered the truth before, and I am still doing so . Sorry if you only like the truth when it makes you money.
Dexamethasone is a corticosteroid that is used in combination with many cancer treatments to reduce inflammation, help prevent nausea, a prevent allergic reactions.
Fezz you are the worst kind of troll by trying to suck in the uneducated to believe whatever side of the trade you are on. Take a hike.
Agreed WHY isn't decade on used in both phase 2 peg studies - 1 answer is potential ion of Abraxane effect- why don't you bring an original idea to the bird- looks like it needs one- someone asked why its so low and dropping- I ask why it's so high.
The dexamethasone was administered in order "to help minimize or prevent muscle and/or joint pain that may be caused by PEGPH20." See http://www.seattlecca.org/newsletters/clinicaltrials-monthly-nov2011.cfm.
Also, not sure about your conclusory statement that Dexamethasone cannot be used with Abraxane. I read Abraxane's entire label, and the following is the only mention of a potential adverse interaction with Dexamethasone (note the distinction between in vitro and what occurs in real life, in vivo):
"In vitro, the metabolism of paclitaxel to 6α-hydroxypaclitaxel was inhibited by a number of agents (ketoconazole, verapamil, diazepam, quinidine, dexamethasone, cyclosporin, teniposide, etoposide, and vincristine), but the concentrations used exceeded those found in vivo following normal therapeutic doses."
You seem to be drawing a lot of dire inferences without a sufficient knowledge base.
Fezz is acting like a person who has an axe to grind. If I owned a large concentrated position and lost a ton of money in one particular stock; I would move on to another stock or just distance myself until the storm clouds pass. Overall, Fezz's objective is extremely myopic and its not objective....thats why everyone must do their own due diligence here.