For one thing we got an OS improvement number which I do not think they had released previously of 13 weeks which is huge in this space. We also know that the statistical significance and efficacy profile continued to show in the data 5 months further into the study. Last data was from May. This data is current as of October. Means that risk of something unforeseen worsening the results decreased. Statistical significance remained great, Hazard ratio remained strong and especially after you exclude those two weird Eastern European countries where they seem to have treatment ideas different from the rest of the world.