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Neurocrine Biosciences Inc. Message Board

  • mswrichmond mswrichmond Jan 7, 2014 8:41 AM Flag

    This drug will replace Tetrabenazine of Valeant without all the side effects for the treatment

    of Chorea for HD,PD, and AZ and OTHER Movement Disorders. Here's an excerpt from an article from Medscape:

    Treatment of HD begins with education about the disease, including its natural history, genetics, and insight-oriented therapy. Although HD is one of few neurodegenerative diseases for which the diagnosis can be made long before the onset of clinical symptoms, and it is therefore an excellent model for testing early neuroprotective treatments, no disease-modifying therapies have been found as yet.[74-76] Until such therapies are available, the management of patients with HD will focus primarily on relief of symptoms designed to improve their quality of life.

    The only drug approved for the treatment of chorea associated with HD is is tetrabenazine, which was approved by the US Food and Drug Administration (FDA) in 2008. There are no other approved drugs for any other symptom of HD. Tetrabenazine is a potent, selective, reversible inhibitor of striatal vesicular monoamine transporter type 2 (VMAT2); it causes depletion of striatal dopamine, and has been shown to be effective in the treatment of a variety of hyperkinetic movement disorders including chorea, tics, and tardive dyskinesia.[77] Although tetrabenazine can cause or exacerbate depression, sedation, akathisia, and parkinsonism, when the dose is increased and adjusted judiciously the drug is effective and safe.[78] In a multicenter, double-blind, placebo-controlled trial (TETRA-HD) of tetrabenazine involving 84 ambulatory patients with HD, tetrabenazine treatment resulted in a reduction of 5.0 units in chorea severity compared with a reduction of 1.5 units on placebo treatment (adjusted mean effect size = -3.5 ± 0.8 UHDRS units [mean ± standard error]; 95% CI, -5.2 to -1.9; P

    Sentiment: Strong Buy

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