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Aethlon Medical, Inc. Message Board

  • robert.vince robert.vince Oct 24, 2013 9:41 AM Flag

    Aethlon Medical (AEMD) Note: Cancer Immunotherapy Article, Introduction to Dr. Douglas Taylor

    Last week, the Wall Street Journal published an informative article on the emergence of cancer immunotherapies designed to augment the immune system's ability to recognize and combat malignant tumors. The oncology community is embracing this new treatment paradigm based on mounting clinical evidence that immunotherapies can produce long-term responses across multiple tumor types when combined with traditional therapies. As per the article, industry analysts project that immunotherapies could represent half of all cancer treatments within the next 10 years. The opportunity in lung cancer alone was referenced as a $6 billion opportunity.
    At least five major drug companies are advancing candidates, including Bristol-Myers Squibb, whose drug Yervoy is already approved for melanoma. Drug mechanisms that inhibit the PD-1 molecular pathway, which cancer cells hijack to evade destruction by the body's immune system, are a primary target in the emerging immunotherapy pipeline. The article also balanced the compelling promise of these candidates with the reality that PD-1 inhibitors and other immunotherapies face significant administration and cost hurdles. Much of the concern is associated with the challenge of stacking an immunotherapeutic drug on top of the toxicity of established therapies such as radiation, chemotherapy, targeted cancer agents or other PD-1 inhibitors. Beyond this challenge, the cost of combining such therapies could prove to be prohibitive considering that Yervoy alone costs $120,000 for four doses administered over 12 weeks.
    From an Aethlon Medical perspective, the Wall Street Journal article serves to reinforce our vision that a medical device can deliver immunotherapeutic benefit to both established and candidate cancer therapies, and do so economically and without added drug toxicity.

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    • Our device strategy targets a survival mechanism deployed by tumors to evade and defeat the immune system of cancer patients. This mechanism, which is not addressed by drug therapies, is the seretion of exosomes by cancerous tumors. Researchers have discovered that tumors release these particles to trigger the death of cancer fighting immune cells and facilitate the spread of metastasis. Additionally, the systemic elimination of exosomes may represent a novel strategy to inhibit the PD-1 molecular pathway. To date, researchers have demonstrated that the Aethlon Hemopurifier® can capture exosomes underlying lymphoma, melanoma, ovarian, and breast cancer. If you are not familiar with the Hemopurifier®, it is a first-in-class medical device that targets the rapid elimination of life-threatening infectious viruses and tumor-secreted exosomes from circulation.
      Based on the recent approval (after 5+ years of effort) of an investigational device exemption (IDE) by FDA, we are preparing to initiate the first U.S. studies of Hemopurifier® therapy in Hepatitis-C (HCV) infected individuals. In studies previously conducted overseas, Hemopurifier® therapy was demonstrated to accelerate viral load depletion in hardest-to-treat HCV patients receiving standard-of-care drug therapy.
      As a result of crossing the IDE approval threshold, we opened the door to advance relationships with medical institutes that have clinical interest in expanding Hemopurifier® indications to include various forms of cancer.

      • 2 Replies to robert.vince
      • Based on the recent approval (after 5+ years of effort) of an investigational device exemption (IDE) by FDA, we are preparing to initiate the first U.S. studies of Hemopurifier® therapy in Hepatitis-C (HCV) infected individuals. In studies previously conducted overseas, Hemopurifier® therapy was demonstrated to accelerate viral load depletion in hardest-to-treat HCV patients receiving standard-of-care drug therapy.

      • When we initiated our first cancer research activities, we were making two intuitive yet forward-looking bets. The first was that exosomes would emerge to become a vital therapeutic target. The second was a belief that novel immunotherapies would rethink the landscape for treating cancer. Today, tumor-secreted exosomes are well-documented therapeutic targets and cancer immunotherapies are expected to take center stage in the cancer treatment arena. There is growing hope that the marriage of traditional cancer therapies with next-generation immunotherapies may someday allow cancer to become a manageable condition much like HIV-infection is managed through a cocktail of treatment mechanisms. At Aethlon Medical, our role is to provide the oncology community with a therapeutic tool that counters the immunosuppressive impact of exosomes without adding drug toxicity to companion cancer therapies.
        In closing, I am providing the scientific viewpoint of Dr. Douglas Taylor on the potential implications of Hemopurifier® therapy in cancer care. Dr. Taylor is credited with the discovery of tumor-secreted exosomes and is a leading published author on the topic. He is also one of the newest members of the Aethlon family as he has accepted the position of Chief Scientific Officer at our Exosome Sciences diagnostic subsidiary.

 
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