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Aethlon Medical, Inc. Message Board

  • robert.vince robert.vince Apr 22, 2014 8:05 AM Flag

    Aethlon Medical (AEMD) CEO Note: Cancer Therapy Publication References Aethlon Medical

    When we initiated our first exosome research program, the medical community generally viewed these particles as nothing more than cellular debris with no biological function. In contrast, we believed that exosomes, also known as microvesicles or extracellular vesicles, suppressed the immune system of cancer patients and that stage of cancer progression correlated directly with quantity of exosomes in circulation. We envisioned the possibility that a medical device could eliminate circulating exosomes and combine to improve the benefit of established cancer therapies without adding drug toxicity.
    Today, I am pleased to inform you that a team of researchers from Harvard Medical School, Massachusetts General Hospital and University of Oxford have published a review article that validates the original rationale of our exosome research and further reinforces our future plan to submit an investigational device exemption (IDE) to the U.S. Food and Drug Administration (FDA) that requests permission to initiate Hemopurifier® studies in cancer patients.
    The article entitled: "Extracellular Vesicles: Emerging Targets for Cancer Therapy" is published in the current issue of the journal "Trends in Molecular Medicine".
    The article reviews recent discoveries that have increased the understanding of extracellular vesicles (EV's) role in tumor development and progression, including immune suppression, angiogenesis, and metastasis. On the basis of this understanding, EV's have emerged to be targets for anticancer therapy. The article then discusses novel therapeutic strategies to target EVs to prevent tumor growth and spread. In this regard, Aethlon Medical is the only organization referenced based on our extracorporeal device strategy to target the elimination of exosomes from circulation of cancer patients.

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