Acquisition of Exclusive Manufacturing and Marketing Rights for DOTATOC
GARCHING, Germany, September 18, 2013 /PRNewswire/ --
•In-licensing of superior DOTA-Tyr3-octreotide
•Pharmaceutical developmentfor treatment of NETs
•Excellent pharmacokinetic properties
ITM Isotope Technologies Munich AG (ITM) today announced that it has entered into an exclusive licensing agreement with Progenics Pharmaceuticals Inc. for pharmaceutical development and commercialization of radiolabeled DOTA-conjugated somatostatin analogue DOTA-[Tyr3]-octreotide (DOTATOC known as Edotreotide) for human oncology therapeutic use. Radiolabeled DOTATOC is a superior agent for safe and highly effective radionuclide therapy of somatostatin receptor positive tumors which offers excellent pharmacokinetic properties and highest affinity to somatostatin receptor subtypes 2 and 5.
Scope of license agreement
The sublicense granted by Progenics Pharmaceuticals Inc. covers exclusive worldwide manufacturing and marketing rights of DOTATOC and certain radiolabeled DOTATOC for human oncology therapeutic use except the countries Albania, Algeria, Bahrain, Bulgaria, Cyprus, Greece, Iran, Iraq, Kuwait, Lebanon, Oman, Qatar, Romania, Saudi Arabia, Syria, Turkey and United Arab Emirates. Further terms of the agreement were not disclosed.
ITM affiliate ITG Isotope Technologies Garching GmbH will develop radiolabeled DOTATOC for treatment of metastatic neuroendocrine tumors. In addition, DOTATOC as precursor is now available and will be distributed in GMP quality in cooperation with a leading supplier of advanced chemicals for nuclear medicine.