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Organovo Holdings, Inc. Message Board

  • transverse.process transverse.process Oct 27, 2013 9:19 AM Flag

    i have some complicated questions if anyone has any useful answers

    so my thoughts on the business model of Organovo:
    -these 3-d printed "organs" cannot replace real humans in clinical trials completely, just partially. this is because the nervous system controls all organs and the body acts with the organs and glands and other tissues under the control of the brain. without these interactions between organs and the brain's control there cannot be a direct comparison so much as a clump of tissue that you can test for certain properties, such as toxicity. companies can probably use Organovo's liver cells to easily (relatively speaking with today's technology) test a chemical or compound for how much it could potentially damage liver or kidney (of cardiac muscle) cells.
    -so, the toxicity stuff could probably be applied to any cells Organovo can print, which could be many different organs potentially. i would think organs that are simpler will obviously be the first candidates. the liver is an amazing organ, but from what i understand its pretty much a clump of cells. the kidneys are more complex. the brain is obviously out of the realm of possibility, like the gallbladder, stomach, and small intestine could be. some glands may be possible, or maybe bone marrow.
    -does anybody know any way to propose a potential value of a contract that Organovo could sign for a company to license this technology in order to test for toxicity to the liver? it is probably the most likely of the organs to suffer from toxicity since it acts as a detoxifier for the body, so I would think all new or different types of chemicals would need to be cleared for toxicity early in testing. Organovo could expedite that process by finding out which chemicals or compounds are toxic early on in trials/testing. how valuable is that ability to filter out toxic stuff early on? or am I missing something of value with this liver tissue?

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