The Jacobus trial is recruiting patients that have been on DAP for over 90 days. It also has trials for LEMs patients that have not been on DAP.. Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome (DAPPER)Detailed Description:
The objectives of the study are to confirm the safety and to test the efficacy of 3,4-DAP in the treatment of LEMS-related weakness.
This is a phase 2 randomized double-blind placebo-controlled withdrawal study in subjects with known clinically active LEMS who have been on a chronic stable dose of compassionate distribution Jacobus 3,4-DAP provided through FDA-approved individual investigator-held INDs.
This study is currently recruiting participants.
..there are several problems if you want approval with this trial...the patients are selected and invited by jacobus and very likely they are enrolling the best responders...to be approved for the entire lems population the trial have to begin without previous treatment with the same compound...