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OncoGenex Pharmaceuticals, Inc. Message Board

  • jetmanbash jetmanbash Aug 24, 2009 10:24 AM Flag

    Heat shock proteins coming of age:

    CYTR CytRx demonstrates statistically significant cellular evidence of both neuroprotection and neuroregeneration in animal stroke study (0.91)
    Co announces that study results demonstrated that arimoclomol exhibited both statistically significant neuroprotective and neuroregenerative effects in brain cells of animals induced with stroke, offering important insights into this drug candidate's mechanism of action. Orally administered arimoclomol is a molecular chaperone amplifier that is believed to help reduce the accumulation of damaged proteins that may play a role in multiple diseases and disorders. In the study, stroke was induced in rats by introducing blood clots into the middle cerebral artery, causing cerebral oxygen deprivation. These stroke-induced rats in groups of 10 received an oral dose of arimoclomol or a control substance daily for 28 days with the initial dose administered either six, 10, 24 or 48 hours after stroke. Sections of brain tissue were then evaluated for each of the following: 1) chaperone protein HSP70; 2) the number of cells with the characteristic DNA cleavage caused by apoptosis; 3) the microglial cell marker IB4-receptor; or 4) a marker for newly developing brain cells called doublecortin. HSP70 and doublecortin were detected with specific antibodies to the respective proteins, DNA cleavage was detected by a standard assay called TUNEL, and IB4-receptor was measured by binding to IB4-ligand

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