Hi Dr. K, I can't presume to speak for the exalted Prince of Darkness, but I suspect that with the FDA's decision on Kynamro due on January 29 people are "buying the rumor." Unfortunately that usually means they'll sell the news, even if it's good, though they'll sell a lot more if it's bad.
Of course there could be something else going on. I don't follow ISIS that closely even though I own a few shares.
Let's see now, I put a S. Buy on Isis last March at $7.16-18 and a sell in the $13 area. Why did it go up, answer: biotechs were getting a play. Dark analyst who bought Isis didn't know antisense from nonsense but it sounded great. Chuckle. Remember almost six years ago when I warned you of the problems with MIPO. Well, here they are again. ZZZZZZZZZZZZZZZ