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OncoGenex Pharmaceuticals, Inc. Message Board

  • mattgrable268@gmail.com mattgrable268 Jul 3, 2013 2:53 PM Flag

    Old phase II OGX-011 trial question

    Im new to the stock and doing my research on custirsen, I'm looking at the phase 2 trial in Journal of Clinical Oncology from 2010, looking at the baseline predicted 24-month survival rate they list a median 25.6%, with 95% confidence interval 20.4 to 31.0% for treatment arm baseline, compared to 19.6% median with 95% CI of 19.0 to 29.4% for placebo.

    My question is whether the median for the placebo group is correct? I haven't seen a case where the median could be so far towards one end of the 95% confidence interval, typically it would be pretty near the middle as it was in the treatment arm. Anyone better at stats than me that can provide some insight?

    Sentiment: Buy

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