Thu, Apr 17, 2014, 10:48 AM EDT - U.S. Markets close in 5 hrs 12 mins

Recent

% | $
Quotes you view appear here for quick access.

OncoGenex Pharmaceuticals, Inc. Message Board

  • green_bar_spike green_bar_spike Aug 9, 2013 1:36 PM Flag

    Trial participants living longer

    keltus1952 hit the nail on the head when he focused on "Trial participants living longer." This also caught my eye. Obviously, in a double-blind study, no-one knows which of the patients (experimental vs. control) are the ones living longer; but the fact is that overall the life of this particular sample (which includes the experimental group) is lengthened so much that there are substantial delays in getting to the end-point of the study and opening up the results for examination.

    I do have considerable background in experimental work and statistics and this simple fact really jumped out at me. Obviously, during the CC, management could not appear to be drawing any conclusions from the fact that participants are living longer. But, at some point, it should be possible to do some statistical analyses (even without opening up the trial data of the experimental vs. control group) and calculate the probability of the entire group of participants' longevity as compared to the longevity of similar patients not in the present trial. If, for example, normally, the median life span of comparable patients is, let us say, 10 months, and the median life span for ALL patients in the present trial at the present time is 13 or 14 months, there should be a way to show statistically, that this is a very improbable event and can only be attributed to the fact that the experimental group is living longer.

    I am sure management is aware of this and will have some analyses done to verify efficacy of the treatment.

    By the way, did you folks notice that this longevity issue was brought up very early on in the CC? This is yet another sign that management thinks it is an extremely important fact and have been preoccupied with it and have been trying to figure out what is happening.

    I think we, as investors, are sitting on a rocket!

    Sentiment: Strong Buy

    SortNewest  |  Oldest  |  Most Replied Expand all replies
 
OGXI
10.65+0.40(+3.90%)10:47 AMEDT

Trending Tickers

i
Trending Tickers features significant U.S. stocks showing the most dramatic increase in user interest in Yahoo Finance in the previous hour over historic norms. The list is limited to those equities which trade at least 100,000 shares on an average day and have a market cap of more than $300 million.