Is ~.02 at a 75% of events interim Considerably More Stringent than ~.05 at 100%.
For this trial (my model -- near linear curves), the difference between those two measures is about 1.5 months (call it 5.5 month MST spread at the former, 4 month MST spread at the latter -- HR of ~.79 vs HR of ~.84).
Is that Considerably More Stringent (CMS)? I dunno. Doesn't feel like it.....
At the Avii interim level (~.0003), we're talking a not quite 9 month MST spread and an HR of ~.695. That is CLEARLY CMS.
One thing I've learned NOT to do is take a CEO's adjectives at face value. We can't have any idea how to translate those three words into thresholds.