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ImmunoGen, Inc. Message Board

  • slumdawg2011 slumdawg2011 Jun 13, 2013 9:37 PM Flag

    Herceptin effective in HER2 negative BC

    FYI from Cancer Research journal:

    "A new study suggests that the regulation of BCSCs by HER2 may extend to breast cancers that do not display HER2 gene amplification. In these tumors, HER2 is selectively expressed in the CSC population, and this expression is regulated by the tumor microenvironment. In mouse models, trastuzumab blocked growth of these HER2-negative tumors when administered in the adjuvant setting but had no effect on established tumors."

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