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  • Pinvestment, Enjoy reading your posts.

    In the later part of your reply to creedster you list the 6 risk factors for the combo therapy. You say that the genetic factor (variance) is one of the major ones.

    Question is, if genetic variance is the major cause of PML in the combo theraphy then don't you think that he return of Tysabri will be more challenging ? Because Avonex has not been reported to casue PML so far. Therefore TYsabri is by default blamed for this event. But if you say that genetic make-up (variance) may be a major factor responsible for PML by Tysabri then, every patient who wants to take Tysabri has to be "gentically screened" for their "tolarence" to Tysabri. This I think is even a bigger problem. What do you think ?

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    • I think that the genetic risk of developing PML is exposed by the dual avonex + tysabri treatment in concert with the steroids that the patients were receiving during disease progression

      it is the same as someone who has a family history of cancer - if they smoke or work in a uranium enrichment factory they will probably develop cancer - if they don't put themselves at additional risk then they may never develop cancer - the environmental stresses you put on your body are able to expose your genetic weaknesses

      • 2 Replies to pinvestment
      • So, uisng your example, Avonex symbolizes a uranium enrichment factory for MS patients ? and therefore use only Tysabri. But so far there is no public knowledge of Avonex causing or promoting PML.

        Also why ahs Elan not come out with any preliminary statement on MRI scans ? Are they obliged to reveal such data to FDA first ?

        Thank you for your reply

    • I think the genetic predisposition becomes a factor in the determination of what happened to those poor 2 PML cases susceptibility due to genetic factors will be tracked and identified, and in the meantime this medicine will be brought back into the marketplace with sufficient warnings and labeling to allow its total and unequivacable distribution to those who need it most,

      and the lawyers and bashers can go fuck themselves.

    • Good question.


    • I think the Sun will come up in the morning.

      The stock market will will be very active this Monday.

      And most unfortunatly the blind bashers will try to cross this freeway of knowledge.

      I'll be looking for your "greasy" spot as I drive by!