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Elan Corporation, plc Message Board

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  • wildwillie1979 wildwillie1979 Mar 12, 2005 10:24 AM Flag

    Facts

    According to the neurologists I've spoken w/ there has not been a confirmation of AIDS in the two patients. in fact, they said if that was the case, it could very well exonerate Tysabri. That's just what I was told and I haven't read any concrete confirmation that would suggest otherwise. privacy issues and perhaps the ridiculous AIDS stigma. the post that got my attention was the one suggesting both patients were at the same hospital. Now THAT could be significant. they might have been mis diagnosed or any other number of things. Appreciate your response. i have a lot riding on this one. best of luck.

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    • haven't found any beta interferon yet

      Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy.

      Re D, Bamborschke S, Feiden W, Schroder R, Lehrke R, Diehl V, Tesch H.

      Department of Internal Medicine I, University of Cologne, Koln, Germany.

      A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions.

      Multifocal leukoencephalopathy and polyneuropathy after 18 years on interferon alpha.

      Finsterer J, Sommer O, Stiskal M.

      Multifocal leukoencephalopathy and sensory-motor polyneuropathy have not been reported as side-effects of long-lasting interferon alpha therapy in a single patient. In a 77-year-old man interferon alpha2b and interferon alpha2a were administered subsequently but continuously since 1984 for hairy cell leukemia. Since early 2000, left-sided hemi-hypesthesia occurred and the patient developed gait disturbance, proximal weakness of the lower limbs, bilateral stocking-type sensory disturbances, and restless leg syndrome. Repeated cerebral magnetic resonance images showed multifocal T2-hyperintense white matter lesions supratentorially. The nerve conduction velocity of the peroneal and sural nerve was reduced. After exclusion of various differential diagnoses of leukoencephalopathy and application of a screening program for polyneuropathy, central and peripheral nervous system abnormalities were attributed to the long-lasting interferon alpha therapy

 

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