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  • pinvestment pinvestment Jun 6, 2005 5:57 PM Flag

    krasner article para 9

    Dr. Douglas R. Jeffery, a neurologist at Wake Forest University School of Medicine in North Carolina, said the patient's symptoms would be ''quite rare" for multiple sclerosis, supporting the physician's diagnosis of PML. ''It sure sounds convincing to me," Jeffery said.

    SO THIS DOCTOR HAS SEEN THE LIST OF SYMPTOMS BUT HAS NOT READ THE CHART AND HAVE ANY OTHER DIAGNOSTIC INFORMATION - BUT IS STILL ABLE TO SAY IT SOUNDS CONVINCING - MAYBE SOMEONE SHOULD ASK HIM IF IT IS NORMAL FOR A DOCTOR NOT TO MAKE A PML DIAGNOSIS WITHIN 8 WEEKS OF TREATING A PATIENT - THIS DOCTOR ALSO DOES NOT KNOW THE MEDICAL HISTORY OR HOW MUCH OR WHEN TYSABRI WAS GIVEN

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    • Guys:

      To both of you: neuro and PIN

      Maybe you have already commented on this, but I would be interested in whether you think that 3 doses of T in conjunction with the other drugs P#4 was taking (Avonex plus one or two others) could have produced PML. I have read in the past that with only three doses of T, it is highly unlikely that T could have triggered PML - Views?.

      I have another question. Usually once a med like T gets put on hold is it not the case that even after it is re-introduced to the FDA with positive data, the FDA will order another round of evaluation; some kind of BLA or the like. This suggests that it could be many months, even a year(s), after the FDA reviews the evidence on T with BIIB/ELN before T could possibly be re-introduced to the market. Do either of you have views on this?

      Thanks for your thoughts.

      Defender

    • As far as Krasner, much ado about a no one.

    • Neuro111,

      It is criminal that this "4th case" has put such a damper on this stock and tysabri the medicine. What a mess.

      It is also unreal that all of this falsehood has dampened the price.

      This board, you, & pin/others have proven how little weight the whole issue really has.

      This stock will recover.

      Thanks for your contributions to this board.

    • I actually didn't hear any rumors at AAN, just info on 1,2 and 3. I don't think there is a 4 and '5', the young girl is not PML (I'm very certain).
      As far as Krasner, much ado about nothing.

    • heard that it was child.

    • Wasn't Dr Douglas Jeffery the neuro at the Meeting in April who was quoted in the Boston Globe article stating that Tysabri "was gone, would never be approved"; and who quickly shown to have a conficting financial or research interest in a 'competing' / alternative MS drug ?

    • Pin, please turn off the caps keys. It really does not help.

      They symptoms do not sound to me like PML unless the onset was gradual. You do not wake up one morning with PML and not be able to talk or write. Of course, that is a presumption on my part as to how this patient presented, it may have been more gradual. But yes, the symptoms do not sound like MS. They do not sound like PML either if the onset was sudden.

      As we all know, these folks like to take quotes out of context. The question could have been:

      Do you think these symptoms could come from MS?

      No.

      That means they have to come from something else, perhaps PML.

      It sure sounds convincing to me.

      -------

      In any event, let us say this person got PML because she wacked out her immune system by taking Avonex + Tysabri + (maybe) 2 "MS Drugs". I think everyone will grant that if you wack the immune system hard enough you get PML. Apparently hard enough means taking Avonex + Tysabri.

      What has changed? Nothing. Combo-therapy is out and has been out since patients 1 & 2.

      It is all the thousand+ patients on mono-therapy that have not developed anything that is the real news here...

      • 1 Reply to billgatesisevilus
      • FWIW, I think its unlikely the '4th' patient is PML because of the 7 week timeframe and assurance on this board that the spinal fluid was negative.

        That said, I am a little concerned about the symptoms. If the aphasia and alexia developed slowly, then PML is definitely in the differential diagnosis. A developing PML focus under Wernicke's area and the adjacent angular gyrus would give these symptoms. Neuropsychiatric symptoms are seen with PML. Tumor and other infection could also give a slow timecourse. If the symptoms developed rapidly, then PML is very unlikely. If more rapid, stroke and MS are more likely.

        I look forward to either company (or other source) publicly reporting further details about patient 4. I hope that the lawyers are not shutting down access as is likely in patient #2. Of course, patients and family reserve their right to privacy.

    • Eoesn't Dr. Jeffrey consult for one of Elan's competitors?

    • a la dr. frist and a diagnosis based on a videotape. you know what's going on. we will get there soon.

 
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