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Volume 27, Issue 1, January 1988, Pages 51–55
Administration of aspartame potentiates pentylenetetrazole- and fluorothyl-induced seizures in mice
Judith M.B. Pinto, T.J. Maher
Department of Pharmacology, Massachusetts College of Pharmacy, 179 Longwood Avenue, Boston, Massachusetts 02115, U.S.A.
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An association has recently been proposed between the incidence of seizures and prolonged consumption of the phenylalanine-containing artificial sweetener, aspartame. Since consumption of aspartame, unlike dietary protein, can elevate phenylalanine in brain, and thereby inhibit the synthesis and release of neurotransmitters known to protect against seizure activity, the effect of oral doses of aspartame on the sensitivity of mice to the proconvulsant agents, pentylenetetrazole and fluorothyl was studied. Doses of aspartame were used which increased phenylalanine more than tyrosine in brain, as occurs in humans after the consumption of any dose of aspartame. Pretreatment with aspartame significantly increased the percentage of animals convulsing after administration of pentylenetetrazole and significantly lowered the CD50 for this convulsant. The average time to onset of seizures induced by fluorothyl in control mice was 510sec; pretreatment with oral doses of 1000, 1500 and 2000 mg/kg of aspartame 1 hr earlier significantly reduced the time required to elicit seizures (394, 381 and 339 sec, respectively). The seizure-promoting effect of aspartame could be demonstrated 30, 60 or 120 min after the 1000 mg/kg dose. The seizures induced by either convulsant were potentiated by equimolar amounts of phenylalanine, a major endogenous metabolite of aspartame, while the other metabolites, aspartic acid and methanol, were without effect. Administration."...
Aspartame can cause blackouts, seizures. Dangerous for drivers. Do not drink much diet coke.
If the leukemia doesn't kill you first. My pal Rumsfeld was a true weasel.. He got it legalized. Nixon, King of Weasels.
Could be, but since it first became available in two-litter Pepsi bottles, I've averaged about 4 liters a day of the Aspartame-sweetened stuff and, at the age of 67, I haven't gotten any leukemia, seizures, blindness, or tumors. I also use aspartame in my coffee and on my breakfast cereal every morning.
So, at least in my case, what you say hasn't been true.
I'm totally amazed as to how little you know about aspartame. If you think the sweetener goes well with KFC, so be it. But, aspartame won't for a minute reduce your girth or prevent you from gaining weight which appears to be your major problem. If you want to live to see eighty, don't look for it on your speedometer. Pay attention to what you chow down. Drinking four to five liters of septic juices a day for months on end tells me of you having your brains in your arms rather than your attic. I never thought for a minute that in your old age you could act so irresponsibly. This one really takes the cake.
Do you realize for one second what you have just said? I now know as to why your whole comportment needs to be fine tuned. It's not the Guru that is not well. It's you as you've just confirmed it in spades.
Thank you Ruffturd for being so candid.