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Alnylam Pharmaceuticals, Inc. Message Board

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  • thirdmeinvestor thirdmeinvestor Jun 1, 2006 6:15 PM Flag

    RNAi and cold sore therapy

    Lieberman's paper I referred to deals with HSV-2 which is sexually transmitted and involved in HIV transmission as well, whereas the new Nature paper deals with HSV-1. However, the latency effect in both types of HSV may involve similar mechanisms; in latency they evade immune detection by not producing proteins, and at the same time using RNA based mechanisms, suppress the cells' last defense, suicide, for their selfish reason, maintenance of infection.

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