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Exact Sciences Corporation Message Board

  • dr_lars_lichtenstein dr_lars_lichtenstein May 17, 2013 2:11 AM Flag

    "Ghost Protocol" - A behind the scenes "game changer" for Cologuards mediocre results.

    Before any of you get too carried away I think it's time that I come forward and share some important information regarding an adjunct study that has been conducted by esteemed colleagues and myself in hopes of taking advantage of inherent deficiencies within the EXAS cologuard studies that have been the subject of so much attention at the Mayo clinic over the past couple of years.
    When the preliminary results were released last month, it came as no surprise that the detection of precancerous polyps fell in the low 40's percentile. This made perfect sense to us as we knew through our collective experience as gastroenterologists that both the small and large intestines are affected by a variety of macro environmental issues as well as direct influences that would produce an inconsistent detection outcome to say the least.
    After a significant level of consideration, we began to work with participants, not only control the test environment but to also control the diet of our subjects for a period of 72 hours prior to collection, and to limit their intake to neutral (rice or oatmeal) then combined with a known and measurable variant, in this case, extract of the plant Bhut Jolokia also known as "Ghost Pepper" . These peppers are hotter than around 98% of all peppers in the world. While in some cases they're known to cause varying degrees of intestinal cramping and in rare cases, hemorrhaging, they are in fact harmless and have little long term effect with the exception of our desired result; their consumption precipitates an exaggerated level of "sloughing" or "shedding off" of the epithilieal tissues that line the intestinal walls.
    As a result of our studies, we were able to duplicate the cologuard test with results far superior to those pubished. In fact our detection rate was on par with late stage cancers measured with accuracy over 98%.
    We have patented our methodologies and have made contact with key sponsors. Will share more as it is reveale

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    • Namaste Larry.
      What a wonderful surprise after all these years. In my spare time, besides video games, I would often "google" to learn the whereabouts of high school classmates. Imagine,being reunited on the Exas Yahoo message board. Small world eh? (I only own a few shares.)
      At Gandhi Tech you were always one of the brightest and most creative. Remember the successful sit -in you organized when the local Mc D's tried to substitute beef paddies for vegan ones? After graduation, I tried acting in Bollywood. It seems that you returned to your homeland and eventually became an esteemed gaterolentologist. Congratulations..
      I currently live with my parents who moved to New York City. We live in a small 2 bed room flat just above the convenience store.
      I'm gonna write to Rhan and Atul about our chance encounter. Thanks for the heads up on you research. If you happen to need more Bhut, I can help as I still have a few connections in Mumbai.
      Regards, Feet

    • Well this post was so clever it deserves a reply even though it was written tongue in cheek. I will address the issues raised as if they were serious.
      1) A search of pub med reveals no evidence of accelerated sloughing of the intestinal lining due to pepper consumption. There is some evidence that consumption of large quantities of peppers can cause inflammation of the colon lining, but this would presumably be quantities that most subjects would find aversive.

      2) Since Exact has exclusive licenses to the markers used in the Cologuard test the Ghost pepper protocol (GPP) will have to find other markers. Since they will have a completely different marker profile, they will have to run their own 12,000 subject FDA trial which will take years to set up and complete.

      3) They will also have to license the 30-40 patents that Exact Sciences generated to extract DNA from stool. This will create a nice royalty stream for Exact as they work on their next set of markers.

      Some advantages that you haven’t noted from the GPP :
      - Consumption of large quantitites of the ghost pepper will cause a solid to liquid transition for the stool thus making collection, and possibly DNA extraction easier.
      - The oatmeal pre-prep can be extended to include large quantities of Haggis which is known for leading to emesis that may further purify the contents of the stool.

      I can’t wait for the peppers errrr I mean papers to appear.

    • Just saw this. Nice post. Thank you for your research Doctor.

    • Good Doctor, folks around here ARE laughing at you, but your thesis is plausible and IMO is worthy of further investigation. The only thing I find suspect is your "airing" of it here on Yahoo message boards; a "known conduit for yellow journalism". Real scientists, at least in this country, do not vet their findings on message boards. Has this study been published in a legitimate forum for peer review?

    • Excellent Doctor. Since, I like to grow hot peppers, I'm going to mail both Tyrone and you a big bucket of my own concoction of "Ghost Pepper" byproduct for a sniff test. It will be comparable to the odor of your message. Enjoy!!

    • Nowhere in your post do you mention that you work at the Mayo or for Exact Science. Do you or dont you?
      And what kind of "royalty" are you talking about demanding from them? You can't patent a PEPPER PLANT!!!!!!!

      • 1 Reply to rannn_ice
      • "You can't patent a PEPPER PLANT!!!" - Or can you? Monsanto has patented many plants including several varieties of high ethanol producing corn. I believe that while EXAS may find itself involved in several lengthy court battles, in the end we will prevail. The question is, will the cost be justifiable in the wake of a mere 42% detection rate for pre cancers. Perhaps Dr Lichtenstein, whom we have not heard from since his initial post would like to clarify further? Has EXAS licensed the Bhut Jolokia enzyme he has isolated ? Was the plant genetically altered to bring about an unusual amount of intestinal wall cell "sloughing" that may have improved our success rate in the Mayo studies? Will the Myriad litigation adversely affect this initiative? Has EXAS even approached Dr Lichtenstein and agreed to license his IP yet? There are many questions that remain unanswered and as such, I shall refrain from buying unless we come to an extremely oversold condition.

    • soooooooo, eat a few peppers or spicy food before pooping??? I guess it's time to get back into Chipolte stock.

    • Dear Dr. Liars,
      BS. Funny, but still BS.

    • not sure it would save any money or lives ... it would effect compliance which is already abysmal .... what about the economics of detecting everything 1.5 cm and smaller? it's only a 'better' mousetrap when the innovation is necessary

    • Sounds wonderful.

      • 1 Reply to cdrucker
      • Actually, this sounds quite brilliant. By optimizing the food intake of lab participants and coupling that with a dosing of a formulated extract of the "ghost pepper", these guys in Sweden (or wherever) were able to get VASTLY superior results over the genius lab jackets we've paid boat loads of money to at the Mayo? Shouldn't THEY thought of this first? Now we're going to be over a barrel with this joker paying royalties for something so obvious it defies logic.

 
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